国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (1): 22-25.

• 综述 • 上一篇    下一篇

宫颈脱落细胞中的DNA甲基化研究

仲肇基,杨佳欣   

  1. 100730 北京,中国医学科学院协和医科大学北京协和医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-02-15 发布日期:2012-02-15

Study of DNA Methylation in Cervical Cytology

ZHONG Zhao-ji，YANG Jia-xin   

  1. Department of Obstetrics and Gynecology，Chinese Academy of Medical Science，Peking Union Medical College Hospital，Beijing 100730，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-02-15 Online:2012-02-15

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摘要： 在宫颈病变发生、发展的过程中，DNA甲基化水平发生一系列改变。以往的研究多是基于宫颈组织的，而近来检测宫颈脱落细胞甲基化的研究越来越多。与宫颈组织相比，用宫颈脱落细胞作为研究对象进行检测安全无创，更方便临床应用，可能成为筛查、诊断宫颈病变和判断宫颈病变预后的有利工具。讨论研究较多的宫颈脱落细胞中基因的甲基化水平与宫颈病变等级的关系及其临床应用。

关键词: 子宫颈, 宫颈上皮内瘤样病变, 细胞学, DNA甲基化

Abstract: Aberrant promoter methylation has been detected in pathogenesis of many cancers，including cervical cancer. During cervical carcinogenesis，there is a series of alteration in the methylation status of host genes. Recently，the role of promoter hypermethylation as a diagnostic tool for cervical cancer screening has been examined in liquid-based cytology samples. Detection of DNA methylation in exfoliated cervical cytology samples is more convenient and minimally invasive than in biopsy tissues. In those samples，researchers are searching for DNA methylation markers selectively indicating high-grade precancerous lesions，in order to increase the accuracy of cervical cytological diagnosis. The methylation markers might be used as a potential biomarker for cancer screening，diagnosis and predicting clinical outcomes. Here，we discuss methylation status of host genes in foliated cervical cytology samples during cervical carcinogenesis and its clinical impact.

Key words: Cervix uteri, Squamous intraepithelial lesion, Cytology, DNA methylation