国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (4): 409-412.

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子宫内膜异位症干细胞与Wnt/β-catenin信号通路

刘君，赵志梅，夏天，么秀洁   

  1. 300193 天津中医药大学（刘君，么秀洁）；天津中医药大学第一附属医院不孕不育科（赵志梅，夏天）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-08-15 发布日期:2015-08-15
  • 通讯作者: 赵志梅

Endometriosis Stem Cells and Wnt/β-catenin Signaling Pathway

LIU Jun，ZHAO Zhi-mei，XIA Tian，YAO Xiu-jie   

  1. Tianjin University of Traditional Chinese Medicine，Tianjin 300193，China（LIU Jun，YAO Xiu-jie）；Department of Infertility，First Teaching Hospital of Tianjin University of Traditional Chinese Medicine，Tianjin 300193，China（ZHAO Zhi-mei，XIA Tian）
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-08-15 Online:2015-08-15
  • Contact: ZHAO Zhi-mei

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被引次数

4

摘要： 子宫内膜异位症（EMs）因其具有侵袭、易复发等特点被称为类肿瘤性疾病。近年随着EMs病因学研究不断深入，子宫内膜中存在干细胞且这些干细胞参与子宫内膜的周期性活动的观点得以提出并陆续被验证，进而EMs干细胞学说逐渐得到认可。在干细胞研究中随着分子生物学方法的应用，证明了越来越多的基因和信号通路参与了干细胞的周期性调节，其中Wnt/β-catenin信号通路是干细胞的重要通路之一。Wnt/β-catenin信号通路以其高度保守、结构复杂性而在多种肿瘤的发生发展中通过影响干细胞增殖周期发挥作用，同时Wnt/β-catenin信号通路参与调节子宫内膜干细胞，这将为EMs的发生、发展及治疗提供新的思路。

关键词: 子宫内膜异位症, 干细胞, 信号传导, β-catenin

Abstract: Endometriosis（EMs） is characterized as class neoplastic disease because of its invasiveness，easy to relapse and other neoplastic diseases character. In recent years，with the development of EMs etiology study，the existence of stem cells in the endometrium and these stem cells are involved in the endometrial cyclical activities have been proposed and validated，and then EMs stem cell theory is gradually being recognized. In the research of stem cell as the application of molecular biology method，a growing number of genes and signaling pathways involved in stem cells proved to be take part in stem cell′s cyclical activity，of which Wnt/β-catenin signaling pathway is one of the most important research pathways of stem cells. Wnt/β-catenin signaling pathway is highly conserved in its structural complexity in the development of a variety of tumors by stem cell proliferation cycle play a role，meanwhile Wnt/β-catenin signaling pathway involved in endometrial stem cell regulation，which would provide new ideas for the occurrence, development and treatment of endometriosis.

Key words: Endometriosis, Stem cells, Signal transduction, β-catenin