国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (3): 267-271.

• 综述 • 上一篇    下一篇

加德纳菌生物膜在难治性细菌性阴道病中的研究

余竑敏，苏婷婷，隋龙   

  1. 200011 上海，复旦大学附属妇产科医院妇科 上海市女性生殖内分泌相关疾病重点实验室
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-06-15 发布日期:2014-06-15

Study of Refractory Bacterial Vaginosis with the Gardnerella Vaginalis Biofilm

YU Hong-min，SU Ting-ting，SUI Long   

  1. Department of Gynecology，Key Laboratory of Female Reproductive Endocrine Related Diseases of Shanghai，Obstetrics and Gynecology Hospital，Fudan University，Shanghai 200011，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-06-15 Online:2014-06-15

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5119

被引次数

9

摘要： 细菌性阴道病（bacterial vaginosis，BV）可增加女性患盆腔炎性疾病的风险，增加对性传播疾病的易感性及导致不良妊娠等后果。BV的发病机制尚不清楚，其产生及复发的致病因素亦十分复杂。综述BV在微生物学及病理生理学方面的基本特征，描述了阴道微生态、产过氧化氢乳杆菌的缺失及导致BV相关致病菌的聚集等现象。讨论了细菌生物膜，尤其阴道加德纳菌生物膜在阴道上皮的黏附，不能有效地被免疫系统清除或完全被抗生素灭活，导致BV治疗后仍有慢性、持续性感染的状况。同时进一步对临床常用的BV治疗方案及针对生物膜特异性治疗的研究进展进行了总结，从而增加对BV的认识。
【关键词】 阴道病，细菌性；抗药性，微生物；抗药性，细菌；加德那菌，阴道；生物膜

关键词: 阴道病, 细菌性, 抗药性, 微生物, 抗药性, 细菌, 加德那菌, 阴道, 生物膜

Abstract: Bacterial vaginosis（BV） can increase susceptibility of women to pelvic inflammatory disease，adverse pregnancy outcome and the risk of acquiring sexually transmitted diseases. Because of the factors causing BV and recurrent BV are complex，its etiology or pathogenesis still remains elusive. This review summarizes the microbiology and pathophysiology aspects of BV to enhance understanding of the vaginal microbiota，which is characterized by the depletion of hydrogen peroxide-producing lactobacilli species and aggregation of bacterial vaginosis-associated bacteria（BVAB）. Bacterial biofilm，formed by Gardnerella vaginalis in particular colonizes and adheres on the vaginal epithelium，can′t be completely eradicated by host immune system or antibiotics，contributing to the chronic and recalcitrant infection. Further outlines on the current clinical therapy and the need to cater to specific biofilm eradication treatment to minimize its recurrence.
【Keywords】 Vaginosis，bacterial；Drug resistance，microbial；Drug resistance，bacterial；Gardnerella vaginalis；Biofilms

Key words: Vaginosis, bacterial, Drug resistance, microbial, Drug resistance, bacterial, Biofilms