国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (2): 126-128.

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血小板反应蛋白与子痫前期的相关性研究

吴惠芬，王晨虹   

  1. 518028 广州医学院研究生院（吴惠芬）：南方医科大学附属深圳市妇幼保健院 （王晨虹）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-04-15 发布日期:2013-04-15

Thrombospondin and the Correlation of Preeclampsia

WU Hui-fen，WANG Chen-hong   

  1. Graduate School，Guangzhou Medical University，Guangzhou 510182，China（Wu Hui-fen）；Shenzhen Maternity and Child Healthcare Hospital，Southern MedicalUniversity，Shenzhen 518028，Guangdong Province，China（WANG Chen-hong）
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-04-15 Online:2013-04-15

PDF (PC)

5087

被引次数

4

摘要： 近年研究表明，子痫前期的一个重要的临床特征是循环系统中血管生成因子和血管生成抑制因子的失衡。血小板反应蛋白（thrombospondin，TSP）来自多种细胞，如血小板、内皮细胞、基质纤维细胞、血管平滑肌细胞、间质细胞和免疫细胞，参与多种细胞功能，TSP有抑制血管形成的作用。TSP可能通过激活内皮细胞的增殖、迁移、黏附及浸润使内皮功能受损，进一步导致子宫螺旋动脉管腔狭窄、闭锁，引起胎盘血流灌注减少，引发子痫前期。

关键词: 凝血酶敏感蛋白类, 先兆子痫, 血管内皮生长因子类, 成纤维细胞生长因子

Abstract: Recently research indicate that an imbalance of maternal circulating pro-and anti-angiogenic factors may play a role in the pathogenesis of preeclampsia. Thrombospondin（TSP） is a protein expressed in various cells such as platelet，
endothelial cells，matrix fiber cells，vascular smooth muscle cells，interstitial cells and immunocyte，which acts as a potent
antiangiogenic agent. TSP affects several cellular functions，including proliferation，motility，adhesion，apoptosis and infiltrate make the endometrial spiral arterioles vessel tone stricture and rejection，induce placenta blood flow reduce，then induce preeclampsia.

Key words: Thrombospondins, Pre-eclampsia, Vascular endothelial growth factors, Fibroblast growth factors