Research Progress of Vascular Endothelial Growth Factor and Related MicroRNA in Endometriosis

doi:10.12280/gjfckx.20200905

Abstract

Abstract:

Endometriosis (EMs) is a common gynecological benign disease, but it has characteristics similar to malignant tumors in behavior, such as distant cell metastasis, invasion, implantation, neovascularization etc. Its pathogenesis has many theories, but its specific mechanism is still under continuous study. The survival and growth of endometriotic lesions depend on adequate blood supply, and angiogenesis is one of the key links. Vascular endothelial growth factor (VEGF) , a heparin-binding growth factor specific for vascular endothelial cells, induces angiogenesis and is the most common proangiogenic factor in the endometrium. MicroRNA(miRNA), a class of short endogenous RNAs, plays an important role in the regulation of gene expression by binding to complementary nucleotide sequences of the targeted messenger RNA. Many studies have shown that miRNA are differentially expressed in EMs and are involved in multiple links in the pathogenesis of EMs. In recent years, more and more studies have shown that miRNA affect angiogenesis in EMs by regulating the expression of VEGF. By analyzing the role of VEGF and its related miRNA in the development of EMs, the pathogenesis of EMs was explored and new targets for EMs treatment were sought.

Key words: Endometriosis, Vascular endothelial growth factors, MicroRNAs, MiR-17-5p, MiR-126

LIU Na-na, TANG Xiao-han, LU Mei-song. Research Progress of Vascular Endothelial Growth Factor and Related MicroRNA in Endometriosis[J]. Journal of International Obstetrics and Gynecology, 2021, 48(3): 272-276.

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