Research Progress of MicroRNA in Endometriosis

doi:10.12280/gjfckx.20201192

Abstract

Abstract:

Endometriosis (EMs) is a common gynecological disease in women of childbearing age. Its clinical manifestation is complicated, often characterized by pain, infertility, intercourse discomfort and other symptoms. In recent years, the incidence of EMs is on the rise, which brings physical and psychological burden to women, and also brings huge medical and economic burden to the society. But its pathogenesis has not been clearly explained. At present, a large number of studies have shown that some microRNAs (miRNAs) with important functions are closely related to the occurrence of EMs. MiRNAs are a class of endogenous non-coding RNA molecules with a length of about 22 bases, which can regulate target genes after transcription and affect protein expression, thus affecting cell activities. Therefore, a comprehensive explanation of the functions of miRNAs in regulating ectopic endometrial cells, such as cell proliferation, apoptosis, cell adhesion and metastasis, and angiogenesis, can provide effective help for the diagnosis, treatment and prognosis of EMs.

Key words: MicroRNAs, Endometriosis, Cell proliferation, Apoptosis, Cell adhesion, Angiopoietin-1

CAO Min, ZHANG Guang-mei. Research Progress of MicroRNA in Endometriosis[J]. Journal of International Obstetrics and Gynecology, 2021, 48(5): 583-587.

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