The Role of Circular RNAs in the Development and Progression of Endometriosis

doi:10.12280/gjfckx.20210907

Abstract

Abstract:

Endometriosis (EMs) is a common benign disease in women of childbearing age, which is characterized by the colonization and growth of active endometrial tissue outside the uterine cavity, the pathogenesis is not clear. Circular RNA (circRNA) is a type of closed circular non-coding RNA which exists widely in eukaryotic cells. Previous researches have confirmed that circRNA has the function of coding protein. On the one hand, circRNA can be used as competing endogenous RNA (ceRNA) combined with microRNA (miRNA) to regulate gene expression. On the other hand, combined with RNA-related proteins to perform biological functions, which makes it a research hotspot. Recent studies indicated that circRNA involved in regulating the proliferation and invasion processes of ectopic endometrial cells, and has a potential to become a diagnosis biomarker and therapeutic target for EMs. However, the research on the mechanism of circRNA in EMs is still in its infancy. Based on the latest research progress at home and abroad, this review summarized the relevant research of circRNA in the biogenesis, forming mechanism, biological functions, the current molecular regulation mechanism in the occurrence and development of EMs, and its biological significance in clinical diagnosis and treatment.

Key words: Endometriosis, RNA, MicroRNAs, Transcription,genetic, Gene expression regulation, Circular RNA

PENG Shu-zhen, ZHANG Ling, LIU Yi, ZHANG Wei, LIU Heng-wei. The Role of Circular RNAs in the Development and Progression of Endometriosis[J]. Journal of International Obstetrics and Gynecology, 2022, 49(2): 150-155.

Figures/Tables 1

References 35

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circRNA种类	表达水平	作用机制	生物学效应
circ_0067301	↓	circ_0067301↓→miR-141-5p↑→Notch1↑	促进侵袭、转移和EMT
circ_0004712	↑	circ_0004712↑→miR-503↓→cyclin D1↓、Bcl-2↓、VEGF-A↑	促进增殖、抗凋亡和血管生成
circ_0008951	↑	circ_0008951↑→miR-29c↑→FKBP4↓	孕酮抵抗
circ_0017248	↑	circ_0017248↑→miR-145↑→ACTG2、TAGLN↑	促进增殖和侵袭
circ_0007331	↑	circ_0007331↑→miR-200c-3p↓→HIF-1α↑	促进黏附和增殖
circ_101102	↓	circ_101102↓→miR-141-5p↑	促进侵袭、转移和EMT
circ_0004712	↑	circ_0004712↑→miR-148A-3p↓→β-catenin↓	促进侵袭和转移
circ_0061140	↑	circ_0061140↑→miR-140-3p↓→Notch2↑	促进增殖、迁移和侵袭

circRNA种类	表达水平	作用机制	生物学效应
circ_0067301	↓	circ_0067301↓→miR-141-5p↑→Notch1↑	促进侵袭、转移和EMT
circ_0004712	↑	circ_0004712↑→miR-503↓→cyclin D1↓、Bcl-2↓、VEGF-A↑	促进增殖、抗凋亡和血管生成
circ_0008951	↑	circ_0008951↑→miR-29c↑→FKBP4↓	孕酮抵抗
circ_0017248	↑	circ_0017248↑→miR-145↑→ACTG2、TAGLN↑	促进增殖和侵袭
circ_0007331	↑	circ_0007331↑→miR-200c-3p↓→HIF-1α↑	促进黏附和增殖
circ_101102	↓	circ_101102↓→miR-141-5p↑	促进侵袭、转移和EMT
circ_0004712	↑	circ_0004712↑→miR-148A-3p↓→β-catenin↓	促进侵袭和转移
circ_0061140	↑	circ_0061140↑→miR-140-3p↓→Notch2↑	促进增殖、迁移和侵袭