The Role of LncRNA in Cervical Cancer

doi:10.12280/gjfckx.20211109

Abstract

Abstract:

Cervical cancer is one of the most common malignancies in women. The morbidity and mortality in China remain high. Persistent infection with human papillomavirus (HPV) is a main risk factor for cervical cancer, but it is not the only factor. The relationship between genetic and epigenetic factors and cervical cancer can not be ignored. In recent years, studies have found that long non-coding RNAs (lncRNAs) are related to the occurrence and development of cervical cancer. Many lncRNAs can be widely involved in the regulation of some key signal pathways as competing endogenous RNA (ceRNA), such as Wnt/β-catenin dependent pathway, mitogen-activated protein kinase (MAPK), phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT), Notch signaling pathway. LncRNAs play an important role in carcinogenesis or tumor inhibition in the occurrence and development of cervical cancer, so that many lncRNAs have become new diagnostic and prognostic biomarkers of cervical cancer. Therefore, this paper reviews the structure and function of lncRNA and the mechanism of lncRNA in cervical cancer.

Key words: Uterine cervical neoplasms, RNA, long noncoding, Competitive endogenous RNA, Signaling transduction, Genes

LI Qi, ZHAO Wei-hong. The Role of LncRNA in Cervical Cancer[J]. Journal of International Obstetrics and Gynecology, 2022, 49(4): 388-392.

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