SIRT2-Mediated Protein Deacetylation and Oocyte Senescence

doi:10.12280/gjfckx.20230739

Abstract

Abstract:

Female ovarian aging is much earlier than other organs of the body. With the age of human fertility delaying, the proportion of women experiencing infertility due to ovarian aging is increasing. Ovarian aging is a natural and physiological process characterized by a decline in the quantity and quality of oocytes. Recently, it was discovered that the silence information regulator 2 (SIRT2) mediated non-histone and histone deacetylation, which is involved in the process of oocyte cellular senescence. Age-related reduction of SIRT2 levels in mammalian follicles leads to meiosis defects, resulting in low-quality oocytes and affecting pregnancy outcomes. Ovarian aging is an inevitable natural and physiological process for senile infertile women. While human assisted reproductive technology has brought hope for infertile women at present, low-quality oocytes will also affect the outcome of assisted reproductive technology. In this paper, we will review the localization of SIRT2, its relationship with oocyte meiosis, and its primary role in it. In addition, SIRT2 mediates connexin 43 (Cx43), histone H4K16, α-tubulin, BUBR1, forkhead box O3a (FOXO3a), and other proteins deacetylation involved in the signaling pathway of meiosis, which provides a new idea for preventing oocyte aging.

Key words: Oocytes, Aging, Sirtuin 2, Proteins, Acetylation, Meiosis

JIN Qing-mei, HAN Qiao-song, LIANG Jing-nan, ZHOU Yue, SUN Zhen-gao, SONG Jing-yan. SIRT2-Mediated Protein Deacetylation and Oocyte Senescence[J]. Journal of International Obstetrics and Gynecology, 2024, 51(1): 99-104.

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