Abstract: The aquaporins are family of small membrane-spanning proteins which have high permeability for water molecule that are expressed at plasma membranes in many cells types involved in fluid transprot. Endometrial cancer is the highest incidence of gynecological malignant tumor， and the endometrial adenocarcinoma is the most common histological type. Long-term estrogen stimulation is one of the causes of the cancer. But the molecular mechanism has not been fully elucidated. AQPs can promote cell growth， angiogenesis， and cell migration, potentially facilitating tumor growth and metastasis. AQPs were overexpressed in endometrial cancer and have certein relationship with the clinicopathological features.

Key words: Aquaporins, Endometrial neoplasms, Estrogens, Neoplasm invasiveness