Abstract: Objective: To discuss the different treatment and prognosis of cervical intra-epithelial neoplasia. Methods: 220 cases of CIN selected by cervical cancer screening were chosen, which were divided into simple follow-up group and treatment group. The simple follow-up group has 116 cases of CIN I and the treatment group has 53 cases of CIN1, 37cases of CINⅡ, 14 cases of CINⅢ. Physical therapy in 50 patients, cervical conization method in 25 cases, LEEP in 20 cases, hysterectomy in 9 cases. All patients were followed for 2 years. Results: At 6, 12, 24 month, simple follow-up group on the natural negative CINI were respectively 29.31%（34/116）, 55.14%（59/107）, 83.51%（81/97）; sustained rate of disease were respectively 69.83%（81/116）, 43.92%（47/107）, 14.43%（14/97）; the first 24 months of simple follow-up group of high-risk HPV negative rate were 27.45%（14/51）, negative rate of low-risk HPV were 47.06%（24/51）, cases of progress were all high-risk HPV-positive. In CIN I treatment group and CIN Ⅱ physical therapy the recurrence rate within 1 year were 4.88%（2/41）and 22.2%（2/9）; CIN Ⅱ and CIN Ⅲ cervical cone biopsy or LEEP patients had no recurrence. At present all patients are continued to follow-up. Conclusions: Most CIN I will fade and HPV naturally clear, but HPV-positive patients should be wary of continuing their progress to a high degree of CIN. Follow-up patients who were satisfactory colposcopy, small lesion, voluntary acceptance. CIN Ⅱ and CIN Ⅲ should be used in the treatment of cervical cone biopsy or LEEP, but CIN Ⅲ requires long-term follow. High grade level lesions of the cervix is not recommended to treat by physical therapy.

Key words: Cervical intraepithelial neoplasia, Diagnosis, Follow-up, Treatment