Abstract: Objective：The purpose of this study was to determine whether the host tissue response in the abdominal hernia rabbit model differs in 2 polypropylene meshes（coated and noncoated）. Methods：24 piece of two different kind polypropylene meshes Gynemesh?誖 and Aspide?誖G819P mesh （coated and noncoated，6 for each Group） 30 mm×30 mm size for each were surgically implanted in six abdominal hernia rabbit model which had six abdominal wall defects for each. Four abdominal wall defects for Coated/noncoated Gynemesh?誖 and G819P mesh，two left as the control. Animas were killed 30（n=2），60（n=2）and 90（n=2） days after surgery. Full-thickness sections of abdominal wall were evaluated included macroscopical examination，histological and immunohistochemical analysis，for example，inflammation，neovascularization，fibroblastic proliferation and collagen formation. Results：Erosion of meshes did not occur in all animals. silk protein-coated low-weight polypropylene meshes induced a mild inflammatory response with minimal fibrosis and good host tissue incorporation within the grafts. Few apoptotic and necrotizing cell were found in noncoated meshes. Conclusions：Coated meshes elicit a mild foreign body reaction，minimal fibrotic response and good host tissue incorporation within the grafts，reducing the inflammatory reaction，fibrosis，tissue adhesion and the generation of mesh-related complication.

Key words: Pelvic floor, Prolapse, Abdominal wall, Fibroins, Polypropylenes, Materials testing, Rabbits