Abstract: Objective： To evaluate the diagnostic value of C-MYC gene on high grade squamous intraepithelial lesions of cervix. Methods： We search the database of PubMed， EMbase， Cochrane Library， CBMR and etc， from checkable date to March 31， 2012. We evaluate documents quality based on the diagnostic test accuracy quality evaluation tools （QUADAS） and the studies meet the requirements were included， data analysis was conducted by Meta-Disc 1.4 software. Results：7 studies with a total of 1180 cases in C-MYC gene were included. The results of meta-analysis showed that the sensitivity，specificity，diagnostic odds ratio of C-MYC gene on high grade squamous ontraepithelial lesion of cervix were 0.52（95% CI 0.47-0.57）， 0.80（95% CI 0.77-0.83）， 3.60（95% CI 1.55-8.39）， respectively. Conclusions： Diagnosis value of C-MYC gene were medium in alone diagnosis high grade squamous ontraepithelial lesion of cervix， and it can be used as an auxiliary clinical diagnosis method with other diagnostic method.

Key words: Genes, myc, Uterine cervical neoplasms, Meta-analysis, Diagnosis