Abstract: Embryonic diseases，that is fetal origins of adult disease states that adverse influences early in development and particularly during intrauterine life can lead to the permanent physiology and metabolic abnormalities，thus subsequently resulting in an increased risk of numerous diseases in adulthood. Placenta plays a critical role in the programme of intrauterine stimulus and preeclampsia，particularly early-onset preeclampsia was closely related to the placenta insufficiency. Increasing evidences from epidemiology and experiments on animals have proven that the development of adult diseases such as hypertension，diabetes and stroke was strongly linked with preeclampsia. This article would state the relationship and the potential mechanism among them.

Key words: Pre-eclampsia, Fetal diseases, Pregnancy complications, Hypertension, Diabetes mellitus, Stroke