Journal of International Obstetrics and Gynecology ›› 2014, Vol. 41 ›› Issue (4): 462-465.

• 综述 • Previous Articles     Next Articles

Bone Morphogenetic Protein 4,Bone Morphogenetic Protein 7 and Polycystic Ovary Syndrome

HUANG Xiao,JIN Jie-wen,WANG Yong   

  1. Medical School of Nanjing University,Nanjing 210093,China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-08-15 Online:2014-08-15
  • Contact: WANG Yong

Abstract: Polycystic ovary syndrome(PCOS) is one of the common endocrine disorder affecting women of reproductive age,and is characterized by oligo- or anovulation,hyperandrogenism and polycystic ovaries. Some findings show that the cause of PCOS has something to do with the abnormal regulation of transcription factors,such as the Transforming Growth Factor-beta(TGF-β) superfamily. Bone Morphogenetic Protein 4(BMP4) and Bone Morphogenetic Protein 7(BMP7) are both important members in TGF-β superfamily, and play an significant role in the folliculogenesis、ovulation and the development and apotosis of granulosa cells in ovary. As a result,in order to know more about the pathogenesis and treatment of PCOS, it is necessary to make clear the regulation function of BMP4 and BMP7 in female reproductive system.

Key words: Polycystic ovary syndrome, Bone morphogenetic proteins, Bone morphogenetic protein receptors