Abstract: Objective：To analyze the relationship between the lymph-vascular space invasion（LVSI） in cervical cancer and other histo-pathologic parameters, in order to provide some guidance for choosing treatment. Methods：Clinical and pathological data of 462 cervical cancer patients were analyzed retrospectively from April 2003 to May 2013 in Shanghai First Maternity and Infant Hospital of which LVSI positive（40%） and 277 cases negative（60%）. An analysis was done in terms of the relationship between LVSI and stage and grade of the disease, as well as lymph-node metastasis and other histo-pathologic parameters. Results：In single variable analysis, the presence of LVSI appeared to have obvious relationship with FIGO staging, tumor size, depth of tumor invasion, lymph-nodes metastasis and whether neoadjuvant therapy, but there was no statistic significance with whatever neoadjuvant therapy use. In multivariable analysis, LVSI appeared to have significant association with other histo-pathologic parameters such as histopathological types, stromal invasive depth, tumor size, parametrial infiltration and lymph-nodes metastasis. And the incidence of LVSI was elevated with the increasing number of parameters. Conclusions：LVSI closely related with other pathological risk factors. LVSI can hint the potent danger of lymph-nodes metastasis, and can provide guidance for clinically treatment.

Key words: Uterine cervical neoplasms, Carcinoma, Blood vessels, Lymphatic vessels, Embolism and thrombosis, Neoplasm metastasis