Abstract: Objective：To investigate the therapeutic effect of succinic acid adenosine methionine combined with dexamethasone in patients with intrahepatic cholestasis of pregnancy and its influences on immune function. Methods：78 patients with intrahepatic cholestasis of pregnancy who were admitted into our hospital from September 2013 to September 2015 were divided into two groups (39 cases in each group). The control group was treated with succinic acid adenosine methionine, while the observation group received succinic acid adenosine methionine combined with dexamethasone. The serum levels of TBA, TBIL, DBIL, ALT, AST, IL-12 and TNF-α in both groups before and after treatment were observed and compared. The level of TNF-α in placenta tissue and therapeutic effect and were compared in the two groups. Results：The therapeutic effect of observation group was better than that in control group (P＜0.05), perinatal outcome of pregnancy maternal and perinatal status of child were also better than control group. After treatment, the serum level of TBA, TBIL, ALT, AST and IL-12 in both groups were lowered than before , the observation group were significantly declined than the control group(P＜0.05). The levels of DBIL, TNF-α and placenta′s TNF-α in observation group were obviously lower than in control group (P＜0.05). For observation group, each index difference before and after the treatment were higher than the control group (P＜0.05). Conclusions：Succinic acid adenosine methionine combined with dexamethasone is marked effective in treating patients with ICP, which can obviously alleviate the patient's clinical symptoms, reduce the blood bile acid, and significantly improve liver function and immune function, improve perinatal outcome of pregnancy maternal and perinatal status of child.

Key words: S-adenosylmethionine, Dexamethasone, Cholestasis，intrahepatic, Pregnancy complications