Abstract: Recent studies have found that the balance regulation of helper T cell type 1 (Th1) / Th2 is closely related to the occurrence, development, treatment and prognosis of pregnancy and gynecological diseases. Th1 cells regulate cellular immunity, mainly promoting inflammation and cytotoxic activities; Th2 cells regulate humoral immunity, mainly stimulating cell differentiation and proliferation, Th1 cells inhibit Th2 cells by synthesizing IFN-gamma, Th2 cells inhibit Th1 cells by synthesizing IL-4, and they interact and regulate each other. Th1/Th2 cell response is physiologically unbalanced in normal pregnancy, and maternal Th2 cytokines inhibit the production of Th1 cytokines. This physiological imbalance can lead to recurrent abortion, premature delivery, preeclampsia, infertility and other pregnancy-related diseases, and cervical cancer, ovarian cancer, endometriosis and other gynecological diseases related to Th1/Th2 balance regulation, but the exact immunological mechanism is still unclear. With a view to a variety of further studies, the immunological treatment of obstetrics and gynecology has opened up new prospects.

Key words: T-lymphocyte subsets, Pre-eclampsia, Abortion, habitual, Uterine cervical neoplasms, Ovarian neoplasms