Journal of International Obstetrics and Gynecology ›› 2018, Vol. 45 ›› Issue (6): 634-637.

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The Research Progress of RNA Molecule in Cervical Cancer

CHEN Chang-xian,XIE Yu-xuan,MO Ling-zhao,SONG Hong-lin,LI Li   

  1. Department of Gynecologic Oncology(CHEN Chang-xian,MO Ling-zhao,SONG Hong-lin,LI Li),Clinical Laboratory(XIE Yu-xuan),Affiliated Tumor Hospital of Guangxi Medical University,Nanning 530021,China;Laboratory of Early Prevention and Treatment for Regional High Frequence Tumor Ministry of Education Key Laboratory,Nanning 530021,China(CHEN Chang-xian,MO Ling-zhao,SONG Hong-lin,LI Li)
  • Received:2018-07-18 Revised:2018-09-18 Published:2018-12-15 Online:2018-12-15
  • Contact: SONG Hong-lin,E-mail:381783170@qq.com;LI Li,E-mail:lili@gxmu.edu.cn E-mail:ccxhs01@163.com

Abstract: The RNA molecules, including messenger RNA (mRNA), microRNA (miRNA), long non-coding RNA (lncRNA) and circular RNA (circRNA), are interrelated and coordinated to form a dynamic molecular network, that is, competitive endogenous RNA (ceRNA) regulatory network. Recent studies have revealed that ceRNA regulatory network plays an important role in the regulation of the pathogenesis, development and prognosis of cervical cancer. Abnormality of any RNA molecule in the ceRNA regulatory network may lead to cervical cancer cell proliferation, invasion, migration or apoptosis through multiple signaling pathways. In this review, we focus on the relationship between RNA molecules such as mRNA, miRNA, lncRNA and circRNA and cervical cancer on the basis of the research progress, aiming at elucidating the molecular mechanism of RNA associated with cervical cancer, so as to provide new ideas for the diagnosis and treatment of cervical cancer.

Key words: Uterine cervical neoplasms, RNA, messenger, MicroRNAs, Long non-coding RNA, Circular RNA, Competitive endogenus RNA regulatory network