Abstract: Objective：To analyze the correlation between the high expression of lncRNAs and the pathological characteristics and prognosis of endometrial carcinoma, and systematically to evaluate its prognostic value in endometrial cancer. Methods: We searched the electronic databases such as Pubmed, Embase, Web of science, CNKI, Wan Fang, VIP from inception to October 9, 2017. Literature selection was performed according to inclusion and exclusion criteria, then quality assessment was carried out, and data was extracted. Revman 5.3 and stata 12.0 software were used for meta analysis. Results: 9 studies (1 Chinese, 8 English) and 775 endometrial cancer patients met the inclusion criteria. The results of meta-analysis showed that high expression of lncRNAs was associated with FIGO stage (OR=2.41, 95%CI: 1.11-5.25, P=0.03), histological grade (OR=2.01, 95%CI: 1.19-3.41, P=0.009), the myometrial invasion (OR=2.29, 95%CI: 1.16-4.51, P=0.02) and lymph node metastasis (OR=4.00, 95%CI: 2.40-6.66, P＜0.000 01), lncRNAs had nothing to do with the PR and ER positive expression (P＞0.05). Patients with high expression of lncRNAs had a shorter OS compared with low expression (HR=2.43, 95%CI: 1.55-3.80). In a subgroup analysis, HOTAIR correlated with OS (HR=3.73, 95%CI: 1.21-11.49). Conclusions: LncRNAs overexpression has an important predictive value for prognosis in endometrial cancer patients. The higher the expression of LncRNAs, the higher the clinical stage and histological grade, the deeper the infiltration of myometrium and the increased risk of lymph node metastasis, the shorter the os and the worse the prognosis.

Key words: Long non-coding RNA, Endometrial neoplasms, Carcinoma; , Clinicopathological features, Prognosis, Meta-analysis