Abstract: Objective：To evaluate the pregnancy outcomes in Rh-negative pregnant women. Methods：We searched the CNKI, VIP, WanFang database, PubMed and Embase databases for the studies about the pregnancy outcomes in Rh-negative pregnant women by computers. Dated from January 1st 1980 to 30th January, 2018. Two reviewers independently screened research paper according to the inclusion and exclusion criteria, extracted data and assessed the risk bias of included studies. Then meta-analysis was performed using RevMan 5.3 software. Results：Only 9 studies with total of 4 122 cases (679 cases were Rh-negative pregnant women and 3 443 were Rh-positive pregnant women)were included in the Meta-analysis. The results of meta-analysis showed that, the incidence of newborn hemolytic disease (RR=6.29, 95%CI: 3.64-10.85, P＜0.000 01) and premature birth (RR=3.05, 95%CI: 1.80-5.15, P＜0.000 1) in Rh-negative pregnant women are higher than Rh-positive pregnant women. Conclusions：Rh-negative pregnant women were prone to neonatal newborn hemolytic disease and premature birth. Therefore, Rh-negative pregnant women and the Rh antibody should be monitored during pregnancy regularly, in order to reduce perinatal complications.

Key words: Rh-Hr blood-group system, Pregnant women, Pregnancy outcome, Meta-analysis