Abstract: Ovarian yolk sac tumor is a kind of ovarian malignant germ cell tumor, accounting for 1% of ovarian malignant tumors. As malignant ovarian germ cell tumors are more common in children and young women, fertility preservation is the key. Ovarian yolk sac tumor is sensitive to chemotherapeutic drugs. Operation combined with postoperative adjuvant chemotherapy is the standard treatment. For the contralateral ovary and uterus not affected by tumor, fertility preservation surgery should be carried out. However, the tumor itself, surgery and chemoradiotherapy may cause infertility in patients, assisted reproductive technology may be needed after surgery. In this paper, through a case report of a patient with ovarian yolk sac tumor undergoing NC-IVF-ET after surgery and postoperative chemotherapy and literature review, the fertility assisted strategy of patients with ovarian yolk sac tumor was discussed.

Key words: Ovarian yolk sac tumor, Ovarian neoplasms, Endodermal sinus tumor, Fertility, Drug therapy, combination, Fertilization in vitro, Embryo transfer