Abstract: PCOS is the most common female reproductive disorder and affects women of childbearing age worldwide. The pathogenesis is not clear. Studies have found that patients with neuroendocrine diseases are associated with a higher incidence of PCOS. The levels of GABA and blood Kisspeptin were increased in patients with PCOS. The levels of testosterone and LH in patients with PCOS are reduced after NK3R antagonists, suggesting that neuroendocrine disorders are one of the pathogenesis of PCOS. Commonly used animal models of PCOS include prenatal androgen model, prenatal AMH model, postpartum androgen model and aromatase inhibitor model. Different models simulate different subtypes of PCOS, and the aromatase inhibitor model reflected the neuroendocrine changes of PCOS better. Clinical and animal models show that GnRH neurons, GABAergic neurons, Kisspeptin neurons and androgens are involved in the regulation of PCOS neuroendocrine. This article reviews the research progress of neuroendocrine in the pathogenesis of PCOS.

Key words: Polycystic ovary syndrome；, Neurosecretory systems；, Neuroendocrine cells；, Gamma-aminobutyric acid；, Gonadotropin-releasing hormone