Abstract: Endometrial cancer is one of the three most common malignant tumors in the female reproductive system. Its pathogenesis involves not only complex biological processes of multiple factors and stages, but also malignant transformation of endometrium stimulated by estrogen without progesterone antagonism for a long time. It is also closely related to abnormal changes of human immune system. Recently, research on tumor immunity has become a hot topic in the mechanism of the endometrial cancer. CD4+ T lymphocyte cells, as the main participants in the immune response, are divided into a series of multi-functional immune cell subsets, including helper cells T1, helper cells T2, helper cells T17, and regulatory T cells, and helper cell T9 and T22 have been newly discovered in recent years. The differentiation regulation and immune function of CD4+ T cell subsets are closely related to the pathogenesis of various tumors and the prognosis of the patients with tumor. Furthermore, the imbalance of cell number and cytokines secreted by each subgroup will promote the progression of many kinds of tumors. However, the research of CD4+ T cell subsets and their cytokines in endometrial cancer is still in the initial stage. This article reviews the role of CD4+ T cell subsets in endometrial cancer in recent years.

Key words: Endometrial neoplasms；, Th1 cells；, Th2 cells；, Th17 cells；, T-lymphocytes, regulatory；, T-lymphocyte subsets；, Cell differentiation； , Cell proliferation