The Value of Placenta Protein 13 in Early Prediction and Treatment of Pre-Eclampsia

doi:10.12280/gjfckx.20200776

Abstract

Abstract:

Pre-eclampsia, a pregnancy-related condition characterized by hypertension and proteinuria after 20 weeks of gestation, remains a major threat to maternal and infant outcomes globally. If this disease is not controlled, it may lead to maternal HELLP syndrome, eclampsia, placental abruption and other complications, some of which may lead to fetal intrauterine growth restriction, and even cause fetal death and serious adverse pregnancy outcomes in utero. However, currently there is no effective biomarker for early prediction of pre-eclampsia. Most scholars believe that pre-eclampsia is the result of a multi-factorial effect mainly due to damage to the placenta, considering the placenta protein 13 (PP13) as one of the placenta protein specificity, high expression in placenta nourish cells, therefore, this review combines the latest literatures at home and abroad, introduces the PP13 in maternal pregnancy physiological factors and its effect in the development process of pre-eclampsia, discusses the PP13 as pre-eclampsia early prediction of potential markers and its application prospect in terms of targeted therapy.

Key words: Pregnancy proteins, Pre-eclampsia, Pregnancy outcome, Forecasting, Placenta protein 13

YANG Yu-ni, YANG Chao, WANG Qu-yuan. The Value of Placenta Protein 13 in Early Prediction and Treatment of Pre-Eclampsia[J]. Journal of International Obstetrics and Gynecology, 2021, 48(2): 178-181.

References 27

[1]	Madar-Shapiro L, Karady I, Trahtenherts A, et al. Predicting the Risk to Develop Preeclampsia in the First Trimester Combining Promoter Variant -98A/C of LGALS13 (Placental Protein 13), Black Ethnicity, Previous Preeclampsia, Obesity, and Maternal Age[J]. Fetal Diagn Ther, 2018,43(4):250-265. doi: 10.1159/000477933. doi: 10.1159/000477933 pmid: 28728156
[2]	李跃萍, 闫庆峰, 胡春霞. 子痫前期发病机制及其预测的研究进展[J]. 基层医学论坛, 2017,21(16):2126-2129. doi: 10.19435/j.1672-1721.2017.16.073.
[3]	Filipek A, Jurewicz E. Preeclampsia-a disease of pregnant women[J]. Postepy Biochem, 2018,64(4):232-229. doi: 10.18388/pb.2018_146. doi: 10.18388/pb.2018_146 pmid: 30656917
[4]	Sammar M, Drobnjak T, Mandala M, et al. Galectin 13 (PP13) Facilitates Remodeling and Structural Stabilization of Maternal Vessels during Pregnancy[J]. Int J Mol Sci, 2019,20(13):3192. doi: 10.3390/ijms20133192. doi: 10.3390/ijms20133192
[5]	黄小玲, 张少玉, 任春霞, 等. 胎盘蛋白13、妊娠相关血浆蛋白一A和胎盘生长因子预测子痫前期的价值[J]. 福建医药杂志, 2017,39(4):97-99. doi: CNKI:SUN:FJYY.0.2017-04-037.
[6]	Sammar M, Dragovic R, Meiri H, et al. Reduced placental protein 13 (PP13) in placental derived syncytiotrophoblast extracellular vesicles in preeclampsia-A novel tool to study the impaired cargo transmission of the placenta to the maternal organs[J]. Placenta, 2018,66:17-25. doi: 10.1016/j.placenta.2018.04.013. doi: 10.1016/j.placenta.2018.04.013 pmid: 29884298
[7]	Balogh A, Toth E, Romero R, et al. Placental Galectins Are Key Players in Regulating the Maternal Adaptive Immune Response[J]. Front Immunol, 2019,10:1240. doi: 10.3389/fimmu.2019.01240. doi: 10.3389/fimmu.2019.01240 pmid: 31275299
[8]	Vokalova L, Balogh A, Toth E, et al. Placental Protein 13 (Galectin-13) Polarizes Neutrophils Toward an Immune Regulatory Phenotype[J]. Front Immunol, 2020,11:145. doi: 10.3389/fimmu.2020.00145. doi: 10.3389/fimmu.2020.00145 pmid: 32117288
[9]	Moser G, Huppertz B. Implantation and extravillous trophoblast invasion: From rare archival specimens to modern biobanking[J]. Placenta, 2017,56:19-26. doi: 10.1016/j.placenta.2017.02.007. doi: 10.1016/j.placenta.2017.02.007 pmid: 28202182
[10]	Gadde R, Cd D, Sheela SR. Placental protein 13: An important biological protein in preeclampsia[J]. J Circ Biomark, 2018,7(1):1849454418786159. doi: 10.1177/1849454418786159.
[11]	颜露春, 朱广源, 李小林, 等. 子痫前期孕妇外周血sFlt-1、PIGF、PP-13、sEng的表达及其与子宫动脉血流的相关性研究[J]. 中国生育健康杂志, 2019,30(3):237-240,247. doi: 10.3969/j.issn.1671-878X.2019.03.009.
[12]	Than NG, Pick E, Bellyei S, et al. Functional analyses of placental protein 13/galectin-13[J]. Eur J Biochem, 2004,271(6):1065-1078. doi: 10.1111/j.1432-1033.2004.04004.x. doi: 10.1111/j.1432-1033.2004.04004.x pmid: 15009185
[13]	曾小燕, 颜建英. 胎盘蛋白13与子痫前期发病的研究进展[J]. 医学综述, 2010,16(7):997-1000. doi: 10.3969/j.issn.1006-2084.2010.07.012.
[14]	Drobnjak T, Jónsdóttir AM, Helgadóttir H, et al. Placental protein 13 (PP13) stimulates rat uterine vessels after slow subcutaneous administration[J]. Int J Womens Health, 2019,11:213-222. doi: 10.2147/IJWH.S188303. doi: 10.2147/IJWH.S188303 pmid: 30988643
[15]	Moser G, Weiss G, Sundl M, et al. Extravillous trophoblasts invade more than uterine arteries: evidence for the invasion of uterine veins[J]. Histochem Cell Biol, 2017,147(3):353-366. doi: 10.1007/s00418-016-1509-5. doi: 10.1007/s00418-016-1509-5 pmid: 27774579
[16]	Sunjaya AF, Sunjaya AP. Evaluation of Serum Biomarkers and Other Diagnostic Modalities for Early Diagnosis of Preeclampsia[J]. J Family Reprod Health, 2019,13(2):56-69. doi: 10.18502/jfrh.v13i2.1910. pmid: 31988641
[17]	Drobnjak T, Gizurarson S, Gokina NI, et al. Placental protein 13 (PP13)-induced vasodilation of resistance arteries from pregnant and nonpregnant rats occurs via endothelial-signaling pathways[J]. Hypertens Pregnancy, 2017,36(2):186-195. doi: 10.1080/10641955.2017.1295052. doi: 10.1080/10641955.2017.1295052 pmid: 28524718
[18]	金小芳, 张宇娇. 不同生化标志物检测用于预测子痫前期的临床价值[J]. 标记免疫分析与临床, 2017,24(9):1039-1042. doi: 10.11748/bjmy.issn.1006-1703.2017.09.022.
[19]	Huppertz B, Meiri H, Gizurarson S, et al. Placental protein 13 (PP13): a new biological target shifting individualized risk assessment to personalized drug design combating pre-eclampsia[J]. Hum Reprod Update, 2013,19(4):391-405. doi: 10.1093/humupd/dmt003. doi: 10.1093/humupd/dmt003
[20]	包丹, 蔡雁. 子痫前期风险预测指标的研究进展[J]. 中国临床研究, 2020,33(10):1435-1438. doi: 10.13429/j.cnki.cjcr.2020.10.033.
[21]	Huppertz B, Sammar M, Chefetz I, et al. Longitudinal determination of serum placental protein 13 during development of preeclampsia[J]. Fetal Diagn Ther, 2008,24(3):230-236. doi: 10.1159/000151344. doi: 10.1159/000151344 pmid: 18753763
[22]	史娜娜, 周芳芳. PP13,PIGF,sFlt-1联合检测诊断及预测早期子痫前期价值[J]. 中国计划生育学杂志, 2020,28(5):734-738. doi: CNKI:SUN:JHSY.0.2020-05-031.
[23]	Meiri H, Osol G, Cetin I, et al. Personalized Therapy Against Preeclampsia by Replenishing Placental Protein 13 (PP13) Targeted to Patients With Impaired PP13 Molecule or Function[J]. Comput Struct Biotechnol J, 2017,15:433-446. doi: 10.1016/j.csbj.2017.09.002. doi: 10.1016/j.csbj.2017.09.002 pmid: 29034064
[24]	王勇, 李发红, 韩娜. 胎盘蛋白13促进妊娠期高血压疾病患者血管损伤修复的作用及机制研究[J]. 现代妇产科进展, 2018,27(8):589-592. doi: 10.13283/j.cnki.xdfckjz.2018.08.007.
[25]	Tan MY, Poon LC, Rolnik DL, et al. Prediction and prevention of small-for-gestational-age neonates: evidence from SPREE and ASPRE[J]. Ultrasound Obstet Gynecol, 2018,52(1):52-59. doi: 10.1002/uog.19077. doi: 10.1002/uog.19077 pmid: 29704277
[26]	Grimpel YI, Kivity V, Cohen A, et al. Effects of calcium, magnesium, low-dose aspirin and low-molecular-weight heparin on the release of PP13 from placental explants[J]. Placenta, 2011,32(Suppl):S55-S64. doi: 10.1016/j.placenta.2010.11.019. doi: 10.1016/j.placenta.2010.11.019
[27]	武丽红, 张斌斌, 黄玲聪. PAPP-A、Netrin-1、PP13及雌三醇水平对胎儿生长受的预测价值[J]. 中国微生态学杂志, 2018,30(4):465-467. doi: 10.13381/j.cnki.cjm.201804022.