Research Progress of Abnormal Uterine Spiral Artery Remodeling during Pregnancy and Pregnancy Complications

doi:10.12280/gjfckx.20201108

Abstract

Abstract:

Uterine spiral artery remodeling is vital for pregnancy. Uterine spiral artery remodeling is mainly the loss of smooth muscle cells in the vascular layer and endothelial cells in the vascular wall. Decidua natural killer cells (dNK), decidual macrophages, trophoblast cells and the interaction between dNK and trophoblast cells are important determinants of adequate remodeling of the spiral artery. Defects in uterine spiral artery remodeling, especially in the muscular layer of the spiral artery, can lead to a variety of pregnancy complications, such as spontaneous abortion in the first trimester, pre-eclampsia, and fetal growth restriction in the second and the third trimester. These not only affect patients′ physical and mental health, but also cause heavy burden and huge economic loss to families and society due to the high cost of diagnosis and treatment. This review summarized the process of uterine spiral artery remodeling during pregnancy and its key influencing factors as well as the relationship between abnormal uterine spiral artery remodeling and pregnancy complications.

Key words: Decidua, Killer cells,natural, Macrophages, Vascular remodeling, Pregnancy complications, Spiral artery remodeling

ZENG Shan-shan, CHEN Dun-jin, CHEN Jing-si, DU Li-li. Research Progress of Abnormal Uterine Spiral Artery Remodeling during Pregnancy and Pregnancy Complications[J]. Journal of International Obstetrics and Gynecology, 2021, 48(4): 376-379.

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