Genetic Polymorphisms and Recurrent Spontaneous Abortion

doi:10.12280/gjfckx.20220432

Abstract

Abstract:

The etiology of recurrent abortion is complex, involving chromosome, immune, endocrine, reproductive tract microenvironment and many other aspects. As research on the etiology of recurrent abortion continues to progress, the influence of genetic polymorphisms on recurrent abortion has gradually attracted widespread attention. Folic acid is an important raw material for DNA synthesis. Changes in the polymorphism of key enzyme genes during metabolism can lead to decreased folic acid synthesis and hyperhomocysteinemia, which increases the risk of recurrent abortion. In addition, when genetic polymorphisms of cytokines and related receptors, sex hormones and related receptors and ralated genes of thrombosis factors is changed, the level of corresponding products will increase or decrease, disrupting the original balance in the body and leading to recurrent abortion. The role of gene polymorphism in the pathogenesis of recurrent abortion is reviewed.

Key words: Abortion, habitual, Polymorphism, single nucleotide, Metabolism, Folic acid, Cytokines, Gonadal steroid hormones, Thrombosis

HE Tian-yu, WANG Fang. Genetic Polymorphisms and Recurrent Spontaneous Abortion[J]. Journal of International Obstetrics and Gynecology, 2023, 50(1): 82-87.

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