Study on the Role of Placental Mitochondrial Function in the Pathogenesis of Pregnancy Complications

doi:10.12280/gjfckx.20230425

Abstract

Abstract:

As the foundation for maintaining normal pregnancy and an important medium for maternal-fetal communication, the placenta can cause various pregnancy complications such as miscarriage, preeclampsia, gestational diabetes, and premature birth when it is in a state of fibrosis, hypoxia, chronic inflammation, insufficient blood supply, and other conditions. These complications can seriously affect women′s health and fetal outcomes. Mitochondria, as the hub of energy metabolism, can increase the level of inflammatory factors in placental tissue, disrupt the balance between oxidation and antioxidation, and resulting in placental functional damage when their dynamics, biosynthesis, oxidative phosphorylation, and other processes are abnormal, thereby promoting the occurrence and development of various pregnancy complications. This article reviews the current research on the impact of placental mitochondrial dysfunction on a variety of pregnancy complications and to explore the potential mechanisms involved.

Key words: Placenta, Mitochondria, Abortion, spontaneous, Pre-eclampsia, Diabetes, gestational

JI En-ting, XU Ya-xuan, ZHANG Chun-ren, HU Min, MA Hong-xia. Study on the Role of Placental Mitochondrial Function in the Pathogenesis of Pregnancy Complications[J]. Journal of International Obstetrics and Gynecology, 2023, 50(5): 497-501.

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