Abstract: Objective：To study the protein expression and clinical significance of breast cancer metastasis suppressor l（BRMS1） and nuclear factor kappa B（NF-κB p50） in cervical carcinogenesis. Methods：The immunohistochemical method（Super Sensitive TM IHC）was used to determine expressions of BRMS1 and NF-κB p50 were in chronic cervicitis tissues，CINⅠ tissues，CINⅡ-Ⅲ tissues and cervical carcinoma tissues. The clinical significance was analyzed with histopalthological records. Results：① The positive rates of BRMS1 in cervical carcinoma ,CINⅠand CINⅡ-Ⅲ tissues were much lower than that in chronic cervicitis tissues, the differences were significant（all P<0.05），moreover the positive expressions were much lower or absent in cervical cancer tissues with ⅡB-Ⅳ stage，depth of invasion>1/2 and with lymph node metastasis, the differences were significant（all P＜0.05）. ②The positive rates of NF-κB p50 in cervical carcinoma，CINⅠand CIN Ⅱ-Ⅲ tissues were much higher than that in chronic cervicitis tissues（all P<0.05），moreover the positive expressions were much higher in cervical cancer tissues with tumor size≥4 cm，poor differentiation，depth of invasion>1/2 and with lymph node metastasis, the differences were significant（all P＜0.05）. ③The expression level of BRMS1 was negatively correlated with that of NF-κB p50 in cervical carcinoma（rs= 0.426，P＜0.001）. Conclusions：It is closely related to cancer cell invasion and metastasis that the expression of BRMS1 decreased significantly，while the expression of NF-κB conversely increased. In addition，BRMS1 may inhibit NF-κB expression in invasion and metastasis of cervical cancer.

Key words: Uterine cervical neoplasms, Carcinoma, Genes, tumor suppressor, Genes, NF-kappa B, Breast cancer metastasis suppressor 1