Abstract: Cervical caner, the second most common gential tract malignancy in women, is a serious threat to women′s health and lives. Besides HR-HPV, some other factors are considered to be the mechanism of cervix neoplasms. This article reviewed the relationship of DNA methylation, especially the tumor-suppressing gene methylation and cervical cancer. Tumor-suppressing gene methylation is a common phenomenon in cervical cancer and is closely related with the carcinogensis. It provides a new way to the research of pathogenesis, screening and treatment of cervical cancer.

Key words: Uterine cervical neoplasms, Gene expression regulation, Genes, tumor suppressor, Methylation