Abstract: Cervical cancer is the most common gynecological malignant tumor. In developing countries, the incidence and mortality of cervical cancer are always high. Although the research on cervical cancer has been widely carried out, its specific mechanism and synergistic factors have not yet been elucidated. In recent years, more and more attention has been paid to the relationship between gene mutations and cervical cancer. Numerous studies have shown that changes in oncogenes, tumor suppressor genes and related regulatory genes are closely related to the development of cervical cancer and the progression of the disease. With the application of genome sequencing technology in cancer, more gene mutations are found in cervical cancer, and the identification of significant mutations can help further lock cancer-driven genes, so significant mutations may be the key to discover the underlying mechanisms of cancer. This overview of recent research status of the newly discovered significant mutations ErbB-3, HLA-A, CASP8 and TGFBR2 in cervical cancer may provide new ideas for the mechanism research, diagnosis and targeted therapy of cervical cancer.

Key words: Uterine cervical neoplasms, Genes, Mutation, Genes, erbB, Caspases, HLA-A antigens, Receptors, transforming growth factor beta, Significantly mutated gene