Research Progress on the Relationship between Folate Metabolism Disorder and Recurrent Spontaneous Abortion

doi:10.12280/gjfckx.20200659

Abstract

Abstract:

For the definition of recurrent spontaneous abortion, different countries and regions have not reached a unified standard in terms of the number of abortions and gestational weeks of abortion. Its etiology is complex, which has been a hot topic for research in recent years. With the deepening of research, many pathogenic factors have been identified, but the etiology of many patients is still unclear, which brings great difficulties to clinical diagnosis and treatment. As a carrier of one carbon unit, folic acid is an important material for nucleic acid synthesis and DNA repair. Its metabolism abnormality can lead to related diseases by interfering with DNA methylation and synthesis, affecting homocysteine level. The folate metabolic pathway is regulated by related enzyme activities, and there are genetic polymorphisms in key enzyme genes, which affect the process of folic acid metabolism by changing the enzyme activity. Recently, more and more studies have confirmed that abnormal folic acid metabolism can increase the risk of recurrent spontaneous abortion, and folic acid intervention can improve the pregnancy outcome and reduce the incidence of recurrent abortion, but the mechanism is still controversial. This article reviews the research progress on the correlation between folic acid metabolism disorder and recurrent spontaneous abortion, and to provide help for the diagnosis and treatment of recurrent spontaneous abortion.

Key words: Abortion, habitual, Folic acid, Metabolism, Homocysteine, Methylation, Chromosome aberrations

YUAN Bi-bo, WANG Qiu-xia, LI Zeng-yan, MA Yan-hong. Research Progress on the Relationship between Folate Metabolism Disorder and Recurrent Spontaneous Abortion[J]. Journal of International Obstetrics and Gynecology, 2021, 48(2): 191-195.

Figures/Tables 1

References 48

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