Research Progress of Non-Coding RNAs Relating to PI3K/Akt Pathway in Pre-Eclampsia

doi:10.12280/gjfckx.20220530

Abstract

Abstract:

Pre-eclampsia is one of the common complications of pregnancy and is an important cause of maternal and perinatal mortality. The disordered functions of placental trophoblast cells are closely associated with the development of pre-eclampsia. Inadequate invasion of placental extravillous trophoblast cells and abnormal spiral artery remodelling are dominant pathologic mechanisms in pre-eclampsia. The PI3K/Akt (phosphatdylinositol-3 kinase/protein kinase B) signalling pathway plays a significant role in regulating proliferation, survival, apoptosis, migration, and invasion of trophoblast cells. MicroRNAs (miRNAs), long non-coding RNAs and circular RNAs belonging to non-coding RNAs (ncRNA) have multi-level regulatory roles on genes and influence the functions of trophoblast cells by regulating the PI3K/Akt signalling pathway, thus contributing to the occurrence and development of pre-eclampsia. This review introduces the recent advances of ncRNAs related to PI3K/Akt signalling pathway in pre-eclampsia in an effort to provide a reference for exploring and discovering key molecules in the pathogenesis of pre-eclampsia.

Key words: Pre-eclampsia, Phosphatidylinositol 3-kinase/protein kinase B signalling pathway, non-coding RNA, Signal transduction

XU Dan-chen, CHENG Wei-wei. Research Progress of Non-Coding RNAs Relating to PI3K/Akt Pathway in Pre-Eclampsia[J]. Journal of International Obstetrics and Gynecology, 2023, 50(1): 54-58.

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