Progress on Pharmacological Prevention and Treatment of Pre-Eclampsia

doi:10.12280/gjfckx.20220660

Abstract

Abstract:

Pre-eclampsia (PE), as a hypertensive disorder of pregnancy, seriously affects maternal and infant health and long-term quality of life. However, clinical intervention for PE is limited to passive management after the oneset of symptoms, which often leads to poor prognosis of mother and infant. Therefore, the research on pre-symptomatic prevention of PE has become a hot topic. Aspirin is currently the most widely used preventive drug for PE. However, with the deepening of the research on the etiology of PE, many drugs have been proved to be used to prevent PE. In recent years, in addition to aspirin, anticoagulants, antioxidants, pravastatin, metformin, oral microbiome and other drugs have made great progress in the prevention and treatment of PE. This article reviews the main drugs that can be used for the prevention and treatment of PE, in order to help the early prevention of PE in clinical practice.

Key words: Pre-eclampsia, Protective agents, Aspirin, Heparin, low-molecular-weight, Antioxidants, Pravastatin, Metformin, Oral microbiome

WANG Yue, XIN Wei-juan. Progress on Pharmacological Prevention and Treatment of Pre-Eclampsia[J]. Journal of International Obstetrics and Gynecology, 2023, 50(1): 59-64.

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