Journal of International Obstetrics and Gynecology ›› 2012, Vol. 39 ›› Issue (1): 18-21.

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Progression of Nuclear Receptor Interacting Protein 1 in Ovulatory Dysfunction

XU Feng,LIU Jia-yin   

  1. Center of Clinical Reproductive Medicine,First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China(XU Feng,LIU Jia-yin);Nanjing Maternal and Child Health Hospital,Affiliated Hospital of Nanjing Medical University,Nanjing 210004,China(XU Feng
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-02-15 Online:2012-02-15
  • Contact: LIU Jia-yin

Abstract: Nuclear receptors function as a group of ligand-dependent transcription factors. Nuclear receptor interacting protein 1(Nrip1),also named as receptor interacting protein 140(RIP140),binding to nuclear receptors in a ligand- dependent manner plays a crucial role in energy homeostasis and ovulatory dysfunction. The anovulatory phenotype of Nrip1 null mice resembles strongly with clinical luteinized unruptured follicle syndrome,so Nrip1 has a paramount concern in the treatment of ovulatory dysfunction and female infertility. Nrip1 could be a therapeutic target for infertility associated with ovulatory dysfunction and a novel development of contraceptive strategies. This review will focus on the molecular biology characteristics of Nrip1,then analyze the biological role and molecular mechanisms of Nrip1 in the ovary to regulate ovulation.

Key words: Nuclear receptor interacting protein 1, Infertility, female, Ovulation inhibition, Ovarian follicle, Mice