Abstract: Objective：To compare the clinical effects and long-period life quality between total pelvic floor reconstruction and transvaginal hysterectomy with vaginal anterior and posterior wall repair in older women with pelvic organ prolapse （POP）. Methods：From February 2008 to February 2009，sixty POP patients were reviewed in our study whose age was over 55 years old.They were all postmenopausal women and POP-Q were stage Ⅲ-Ⅳ. The study group contain of 30 cases used the mesh of total pelvic floor reconstruction，and the control group adopted conventional surgical transvaginal hysterectomy with vaginal anterior and posterior wall repair in 30 patients. We regular followed up all women last 5 years in outpatient by POP-Q and questionnaire （PFDI-20） which were used to evaluate the life quality. Results：In the study group and the control group，operation time [（107.83±13.00）min vs. （127.50±13.25）min]，bleeding [（194.67±21.13）mL vs. （220.67±28.15）mL]，total cost of hospitalization[（32 488.38±3 408.43）￥ vs. （13 811.41±2 634.89）￥]，had statistical significances （P＜0.05）. There was 1 case recurrence to Ⅱ stage in the study group and 5 cases in the control group by POP-Q score postoperative 5 years. Postoperative 5 years, PFDI-20 scores in the two groups were compared，there were no statistical significance after 1，6 months opposite. There were statistical significance after 1，2，5 years，the women had lower scores and higher quality of life in the study group. Conclusions：The total pelvic floor reconstruction was lower recurrence rate，higher quality of life and cost more than the traditional vaginal hysterectomy with vaginal anterior and posterior wall repair in older women with pelvic organ prolapse.

Key words: Pelvic organ prolapse, Hysterectomy, transvaginal, Control groups, Treatment outcome, Quality of life