Abstract: Objective：To compare the efficacy of different gray-scale changes in adenomyosis treatment by high intensity focused ultrasound（HIFU）. Methods：Retrospective analysis the gray-scale changes of 60 uterine adenomyosis patients treated with HIFU， compared the gray-scale changes with contrast MRI 1 day after treatment， analysis the relationship of different gray-scale changes compared with the treatment dosage，treatment time，intensity of treatment and non-contrast area of MRI. Results：There was no significant different of non-contrast area of contrast MRI between bolus and integrate changes of gray-scale（P＞0.05）. The contrast MRI shows no statistic difference of ablation ratio， volume of ablation and treatment intensity between these two groups 1 day after the therapy procedure， however， the treatment dosage and treatment time of integrate gray-scale change group was much more than the bolus gray-scale change group（P＜0.05）. There was no significant statistic difference of side effects between two groups（P＞0.05）. Conclusions：This study shows that the integrate gray-scale changes can reflect the HIFU ablation efficacy of uterine adenomyosis. To reduce the risk of treatment， there were no necessary to get bolus gray-scale changes during the therapy.

Key words: Ultrasonic therapy, Uterine diseases, Catheter ablation, Magnetic resonance imaging, Retrospective studies