国际妇产科学杂志

国际妇产科学杂志 ›› 2009, Vol. 36 ›› Issue (5): 398-400.

• 综述 • 上一篇    下一篇

可溶性CD105与子痫前期

何尧;董旻岳   

  1. 312000 绍兴市妇幼保健院(何尧);浙江大学医学院附属妇产科医院(董旻岳)
  • 收稿日期:2008-08-05 修回日期:1900-01-01 出版日期:2009-10-15 发布日期:2009-10-15

Soluble Endoglin and Preeclampsia

HE Yao;DONG Min-yue   

  1. Shaoxing Women and Children’s Hospital, Shaoxing 312000, China（HE Yao ）; Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China（DONG Min-yue）
  • Received:2008-08-05 Revised:1900-01-01 Published:2009-10-15 Online:2009-10-15

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摘要： 可溶性CD105（sCD105）是一种存在于血液中分子质量为65 ku的蛋白质，氨基酸序列对应于CD105蛋白氨基端的可溶性结构，
可能是CD105经酶解脱落而成。子痫前期患者循环sCD105显著增高，而且sCD105增高发生在出现子痫前期临床症状前6～10周，其水平与子痫前期
发病妊娠周及病情相关。在体外，sCD105可抑制转化生长因子β1（TGF-β1）诱导的人脐静脉内皮细胞的血管生成作用。注射载有sCD105基因的
腺病毒可引起小鼠血管通透性增高，导致血管内皮细胞受损，并可使其血压增高，出现蛋白尿和其他类似子痫前期的病理变化。sCD105在子痫前
期的变化及其在发病中的作用是子痫前期病因学与病理生理学研究的最新进展之一。

关键词: CD105, 子痫前期, 妊娠

Abstract: Soluble endoglin（sEng, sCD105）is a 65 ku serum protein and its aminoacid sequence corresponds to N-
terminal soluble structure of full-length endoglin. It may be shed by membrane type matrix metalloprotease-1（MT1-MMP）. The
serum level of sEng was elevated in preeclamptic individuals and correlated with disease severity and gestational weeks.
Besides, it was elevated 6-10 weeks before the onset of preeclampsia. sEng blocks transforming growth factor （TGF）-β1-
mediated formation of human umbilical vein endothelial tubes in vitro and induces vascular permeability and hypertension in
pregnant rats in vivo. The research of the effect of sEng in preeclampsia is one of the recent progresses in the pathogenesis
of preeclampsia.

Key words: Endoglin, Preeclampsia, Pregnancy