国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (4): 237-240.

• 综述 • 上一篇    下一篇

缝隙连接在妊娠过程中的作用及其调控机制

黄科华，颜建英   

  1. 350004 福州袁福建医科大学研究生学院(黄科华)；福建医科大学教学医院福建省妇幼保健院妇产科(颜建英)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-08-15 发布日期:2010-08-15
  • 通讯作者: 颜建英

Roles and Regulations of the Gap Junction During Pregnancy

HUANG Ke-hua， YAN Jian-ying   

  1. Postgraduate Institute of Fujian Medical University， Fuzhou 350004， China （HUANG Ke-hua）； Department of Gynaecology and Obstetric， Fujian Medical University Teaching Hospital Fujian Maternity and Child Health Hospital， Fuzhou 350001， China （YAN Jian-ying）
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-08-15 Online:2010-08-15
  • Contact: YAN Jian-ying

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摘要： 缝隙连接（gap junctions，GJs）沟通相邻两个细胞的胞质，介导离子、第二信使和小分子代谢物的交流及电、生化耦联，调节细胞的增殖、分化和代谢等过程。GJs数量和功能状态受多种机制调控，在机体组织内处于动态变化中。妊娠过程中，子宫GJs的变化适时调整子宫平滑肌细胞和内膜细胞的增殖分化，调节子宫平滑肌的收缩性，使子宫适应妊娠不同阶段的要求，在胚胎植入、胎盘和胚胎发育、分娩发动和调节产程及妊娠结局中都起着不可缺少的作用。

关键词: 缝隙连接, 连接蛋白43, 调控机制, 妊娠, 分娩

Abstract: Gap junctions， which are specialized regions in cellular membranes， allow intercellular communication and the transfer of ions， second messengers， and small metabolites between adjacent cells. They not only mediate electrical and biochemical coupling between cells but also regulate many physiological events， including cell proliferation， differentiation and metabolism. Due to the regulation of multiple mechanism， GJs exist dynamically. During one's pregnancy， GJs timely adjust the cells proliferation and differentiation in myometrium and endometrial， then regulate uterine contraction to suit different stages of pregnancy. Thus， GJs play an essential role in the embryo implantation， placenta and embryo development， onset of labor even the regulation of parturient and pregnancy outcome.

Key words: Gap junction, Connexin 43, Regulation, Pregnancy, Parturition