国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (5): 306-310.

• 综述 • 上一篇    下一篇

人乳头瘤病毒E2蛋白结构和功能研究进展

吴海静, 查 晓 ,张国楠   

  1. 610041　成都，四川省肿瘤医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-10-15 发布日期:2010-10-15
  • 通讯作者: 张国楠

Progress in Structrue and Function of the Human Papillomavirus E2 Proteins

WU Hai-jing, ZHA Xiao, ZHANG Guo-nan   

  1. Sichuan Cancer Hospital, Chengdu 610041, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-10-15 Online:2010-10-15
  • Contact: ZHANG Guo-nan

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摘要： 高危型人乳头瘤病毒（HPV）是导致宫颈癌的主要原因。HPV E2蛋白在病毒的转录和复制调节中起着重要的作用。其主要由氨基端转录活化结构域、羧基端DNA结合域以及可变的铰链区组成。HPV E2基因的突变或整合和致癌机制有关。HPV E2蛋白能抑制E6和E7蛋白表达，HPV整合常在E2基因处发生断裂缺失，而E2基因的缺失导致E6和E7蛋白的过表达。就有关HPV E2蛋白的结构和功能的研究进展综述，为HPV E2蛋白在致癌机制中作用的研究提供理论基础。

关键词: 乳头状瘤病毒科, 宫颈肿瘤, 病毒蛋白质类, 突变

Abstract: High-risk human papillomaviruses（HPV） are the main pathogen in cervical cancer. HPV E2 protein plays key roles in the regulation of viral gene transcription and DNA replication. It is composed of a COOH-terminal DNA-binding domain, an NH2-terminal transactivation domain and a flexible hinge. The E2 protein can repress the transcription of the oncogenes E6 and E7. Mutation or integration of the E2 protein is associated with cervical carcinogenesis. The genome integration of HPV usually disrupts E2 gene and causes an absence of E2 gene sequences. The lack of E2 gene could lead to the upregulated expression of E6 and E7 protein. The review will concentrate on the advances in the structure and function of HPV E2 proteins. Understanding the structure and function of HPV E2 proteins might provide a basis for the studies on cervical carcinogenesis.

Key words: Papillomaviridae, Uterine cervical neoplasms, Viral proteins, Mutation