国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (1): 10-13.

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妊娠期巨细胞病毒感染诊断研究进展

沈凤贤,吕时铭   

  1. 310006 杭州,浙江大学医学院附属妇产科医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-02-15 发布日期:2013-02-15
  • 通讯作者: 吕时铭

Update on Diagnosis of Cytomegalovirus Infection During Pregnancy

SHEN Feng-xian， LYU Shi-ming   

  1. Women′s Hospital， School of Medicine， Zhejiang University， Hangzhou 310006， China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-02-15 Online:2013-02-15
  • Contact: LYU Shi-ming

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5132

被引次数

13

摘要： 人巨细胞病毒（cytomegalovirus，CMV）是最常见的先天感染病毒。胎盘细胞感染CMV致胎盘病理改变和胎儿感染CMV导致严重的出生缺陷，对优生优育是严峻的挑战，长期以来各国学者一直致力于先天性CMV感染及其出生缺陷的防治研究。妊娠妇女的原发感染或者继发感染均可引起先天性CMV感染，妊娠前或者妊娠期CMV血清学筛查对于发现高危妊娠妇女非常重要，IgG抗体亲和力测定方法为现有IgG和IgM检测提供了很好的信息补充。一旦确诊妊娠妇女感染CMV，胎儿预后的评估非常重要，羊水CMV检测和影像学检查一方面可以用于宫内感染的诊断，另一方面也可以提供一定的胎儿预后信息。

关键词: 巨细胞病毒, 妊娠, 产前筛查, 产前诊断

Abstract: Human cytomegalovirus（CMV） is the most common pathogene of congenital viral infection. Pathological changes of placenta resulted from CMV infection of placenta combined with cytopathy caused by fetal infection induce serious birth defects， which will be severe challenges to aristogenesis rearing of the state. For a long time， scholars in different countries have been working together to prevent and control symptomatic congenital CMV infection. Both primary and secondary maternal infection can cause intrauterine transmission. CMV serological screening is important for identifying high risk pregnancy. HCMV-specific IgG avidity assay provides more information besides IgG and IgM testing. Once we prove maternal CMV infection， fetal prognosis assessment is most critical. Amniotic fluid CMV-DNA detection and imaging studies could be used to diagnosis of intrauterine infection and fetal prognosis.

Key words: Cytomegalovirus, Pregnancy, Prenatal screening, Prenatal diagnosis