国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (5): 464-465.

• 论著 • 上一篇    下一篇

内皮细胞特异性分子1在宫颈癌组织中表达及临床意义

李 倩, 徐伏兰, 周 琦, 程 黎   

  1. 432100 湖北省孝感市，孝感市中心医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-10-15 发布日期:2013-10-15
  • 通讯作者: 周 琦

The Expression and Clinical Significance of ESM-1 in Cervical Cancer

LI Qian，XU Fu-lan，ZHOU Qi，CHENG Li   

  1. Department of Obstetrics and Gynecology，Center Hospital of Xiaogan，Xiaogan 432100，Hubei Province，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-10-15 Online:2013-10-15
  • Contact: ZHOU Qi

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摘要： 目的：探讨内皮细胞特异性分子1（ESM-1）在宫颈癌组织中的表达情况及其临床意义。方法：随机选取在孝感市中心医院的正常体检者、慢性宫颈炎和宫颈上皮内瘤变（CIN）患者各50例；宫颈癌患者50例，采用酶联免疫吸附测定（ELISA）和免疫组织化学方法检测ESM-1蛋白的表达情况，并比较不同年龄、病理分级、临床分期及淋巴结转移患者的ESM-1表达情况。结果：两种不同检测方法均提示与正常组织、宫颈炎和CIN相比，宫颈癌患者ESM-1蛋白的表达升高（P＜0.05）。不同发病年龄、病理分级、临床分期及有无淋巴结转移患者其表达水平不同（P＜0.05）。结论：ESM-1在宫颈癌组织中的表达明显增加，ESM-1有望成为监测宫颈癌发生发展的重要指标之一。

关键词: 宫颈肿瘤, 内皮细胞, 酶联免疫吸附测定, 免疫组织化学

Abstract: Objective：To explore the expression and clinical significance of endothelial cell specific molecule-1 （ESM-1） in human cervical cancer. Methods：200 patients were randomly selected in Xiaogan Central Hospital，normal women，chronic cervicitis，CIN and cervical cancer were 50 cases separately，using ELISA method and immunohistochemical method to detect the expression of ESM-1 protein，and comparing its expression between different age，pathological grades，clinical stages and lymph node metastasis. Results：Compared with the normal cervical tissue，the cervicitis tissue and the CIN tissue，the expression of ESM-1 in cervical cancer was significantly increased（P＜0.05）. And its expression was statistically correlated with age，pathological grades，clinical stages and the lymph node metastasis （P＜0.05）. Conclusions：ESM-1 is expected to become one of the important indicators in the development of cervical cancer.

Key words: Uterine cervical neoplasms, Endothelial cell, Enzyme-linked immunosorbent assay, Immunohistochemistry