国际妇产科学杂志

国际妇产科学杂志 ›› 2018, Vol. 45 ›› Issue (5): 527-530.

• 综述 • 上一篇    下一篇

宫颈癌HPV预防性疫苗的研究进展

姜波玲，卢媛   

  1. 430060  湖北省武汉市武昌区妇幼保健院
  • 收稿日期:2018-06-21 修回日期:2018-07-30 出版日期:2018-10-15 发布日期:2018-10-18

Research Progress on the HPV Preventive Vaccine of Cervical Cancer

JIANG Bo-ling，LU Yuan   

  1. Maternal and Child Health Care Hospital of Wuchang District, Wuhan 430060, China
  • Received:2018-06-21 Revised:2018-07-30 Published:2018-10-15 Online:2018-10-18

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摘要： 人乳头瘤病毒（HPV）感染是常见的性传播疾病之一。高危人乳头瘤病毒（hrHPV）持续感染是宫颈癌前病变及宫颈癌的主要危险因素。HPV16和HPV18型导致全球大约70%的宫颈癌。宫颈癌普查可减少宫颈癌发生的危险，但不能阻止HPV的感染。很多报道表明，有效的HPV疫苗可以减少HPV相关的宫颈癌、生殖道疣状物的发病率和死亡率。因此，为了有效预防这类疾病，全世界开展了HPV预防性疫苗的研究。目前临床应用的HPV疫苗有HPV 2价疫苗、4价疫苗及9价疫苗，它们可以有效预防相应HPV类型的感染，从而大量减少与此相关的宫颈病变及宫颈癌的发病率和死亡率。本文就HPV、宫颈癌及这3类HPV疫苗的免疫原性、接种剂量的数量和临床应用进行综述。

关键词: 乳头状瘤病毒科, 宫颈肿瘤, 乳头状瘤病毒疫苗

Abstract: Human papillomavirus (HPV) is one of the common sexually transmitted diseases. High-risk human papillomavirus (hrHPV) persistent infection is a major risk factor for cervical precancerous lesions and cervical cancer. HPV types 16 and 18 cause about 70% of cervical cancer worldwide. Cervical cancer screening can reduce the risk of cervical cancer, but it can not prevent HPV infection. Many reports indicate that an effective HPV vaccine can reduce HPV-associated cervical cancer, genital tract spasm morbidity and mortality. Therefore, in order to prevent such diseases effectively, the research on HPV preventive vaccines has been carried out worldwide. At present, the HPV vaccines for clinical application include HPV 2-valent vaccine, 4-valent vaccine and 9-valent vaccine, which can effectively prevent the infection of the corresponding HPV type, and greatly reduce the incidence and mortality of cervical lesions and cervical cancer. This article reviews HPV, cervical cancer, the immunogenicity and number of inoculation doses and clinical application of these three types of HPV vaccines..

Key words: Papillomaviridae, Uterine cervical neoplasms, Papillomavirus vaccines