关键词: RNA, 长链非编码；, 糖尿病, 妊娠；, 细胞增殖；, 细胞凋亡；, 胰岛素抗药性

Abstract: Gestational diabetes mellitus (GDM) is a disease unique to pregnancy. Because abnormal blood glucose and poor blood glucose control are not found as early as possible, it often has adverse effects on pregnancy outcomes and neonates. In recent years, with the continuous research of long non-coding RNA (lncRNA), it has been found that lncRNA not only affects tumors, obesity, metabolic diseases, cardiovascular and cerebrovascular diseases, but also plays an important role in the occurrence and development of GDM. LncRNA is differentially expressed in cord blood of patients. It can affect the disease through the lncRNA-miRNA axis, or by affecting downstream genes, or interacting with other genes, resulting in undesirable pregnancy. In-depth understanding of the mechanism of action of lncRNA related to GDM and further exploration of the molecular basis of the development of GDM may help us to timely predict and treat related diseases. This article reviews the research progress of lncRNA related to GDM in order to prevent and treat the disease better.

Key words: RNA, long noncoding；, Diabetes, gestational；, Cell proliferation；, Apoptosis；, Insulin resistance