国际妇产科学杂志

国际妇产科学杂志 ›› 2019, Vol. 46 ›› Issue (4): 440-443.

• 标准与指南 • 上一篇    下一篇

“2019 SOGC临床实践指南：硫酸镁对胎儿的神经保护作用”解读

唐宇平，韩欢，应豪   

  1. 200040 上海，同济大学附属第一妇婴保健院产科
  • 收稿日期:2019-04-26 修回日期:2019-05-27 出版日期:2019-08-15 发布日期:2019-08-15
  • 通讯作者: 应豪，E-mail：stephenying_2011@163.com E-mail:stephenying2011@51mch.com
  • 基金资助:
    上海市卫生和计划生育委员会面上项目（201740109）；国家自然科学基金面上项目（81771600）；上海申康医院发展中心市级医院新兴前沿技术联合攻关项目（SHDC12017120）上海市科学技术委员会科技支撑项目（17411950600）

The Interpretation of "2019 SOGC Clinical Practice Guideline: Magnesium Sulphate for Fetal Neuroprotection"

TANG Yu-ping，HAN Huan，YING Hao   

  1. Department of Obstetrics，Shanghai First Maternity and Infant Hospital，Tongji University School of Medicine，Shanghai 200040，China
  • Received:2019-04-26 Revised:2019-05-27 Published:2019-08-15 Online:2019-08-15
  • Contact: YING Hao，E-mail：stephenying_2011@163.com E-mail:stephenying2011@51mch.com

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摘要： 脑性瘫痪（cerebral palsy，CP）是早产儿常见且严重的并发症，严重威胁早产儿健康。越来越多的证据表明，产前应用硫酸镁进行神经保护可减少早产儿CP的发生。2019年加拿大妇产科医生协会（The Society of Obstetricians and Gynaecologists of Canada，SOGC）归纳和整理了硫酸镁胎儿神经保护作用的最新临床研究证据，针对使用硫酸镁的孕龄、时机、给药方案、是否需要二次用药及新生儿复苏等临床问题，给出了相应临床意见和推荐。现对其推荐要点进行解读，以期为我国医务工作者提供借鉴。

关键词: 硫酸镁, 早产, 脑瘫, 死亡, 神经保护

Abstract: Cerebral palsy (CP), a common and serious complication for premature infants, seriously threatens the health of premature infants. More and more evidence have shown that antenatal application of magnesium sulfate for fetal neuroprotection can decrease the incidence of CP in preterm infants. Based on the latest clinical research evidence of magnesium sulfate for fetal neuroprotective effect, The Society of Obstetricians and Gynaecologists of Canada(SOGC) developed the clinical practice guideline in 2019. This guideline provide opinions and recommendations on the gestational age, time and dosage regimen of using magnesium sulfate, whether you need a repeat course of antenatal magnesium sulfate and neonatal resuscitation. This article interpreted the main points of the guideline so as to provide reference for Chinese medical staffs.

Key words: Magnesium sulphate, Preterm birth, Cerebral palsy, Death, Neuroprotection