Abstract: Acute fatty liver of pregnancy（AFLP） is a serious complication in the late stage of gestation, which has complicated clinical manifestation with onset suddenly. It has serious maternal and perinatal mortality rate. The pathogenesis is not clear until now, since previous researches indicate that its outbreak mainly link to fatty acid oxidation deficiency（FAOD）. Recent years researches express its etiology not only relate with long-chain 3 hydroxyacyl-COA dehydrogenase（LCHAD）, but also with integrated factors like shortage of short or medium-chain acyl-CoA dehydrogenase, variable or imperfect gene part of the mother and fetus, the accumulation of toxic caused by oxidative stress, the microbial infection including the germ helicoids and virus, hormone shift, the body mass index（BMI） and nutritional conditions change etc. All the various factors can relate and affect each other and present many different natures.

Key words: Pregnancy complications, Fatty liver, Lipid metabolism, Pre-eclampsia, Acute disease