Abstract: Ovarian cancer is the third common cause of cancer-related mortality among women, but it is the leading cause of death from gynecologic cancers. More than 70% of the women are diagnosed at late stage disease. The reason for this is that the tumor, which develops from the ovarians located in the peritoneal cavity, may grow quite large and metastasize before it is diagnosed because of lack of symptoms. Moreover, it has a high recurrence rate even with optimal cytoreductive surgery and effective chemotherapy. So the 5-year overall survival rate for women diagnosed with late stage disease is only about 30%. Early diagnosis, effective treatment and reduce the recurrence of ovarian cancer have important impacts on prognosis. Researchers dedicated to finding indicators, such as CA125, D-dimer, which can be used in early diagnosis of ovarian cancer, treatment response monitoring and prognosis. In this paper, CA125 and D-dimer in the value of ovarian cancer start review.

Key words: Ovarian neoplasms, CA-125 antigen, Diagnosis, Prognosis, D-dimer