Abstract: Objective：To discuss the influence of total irradiation on the human endometrial carcinoma xenografts in the ovariectomized nude mice. Methods：One week after the ovariectomy，the female nude mice were randomly distributed into two groups：non-irradiated group and irradiated group. The endometrial cells，which had been cultured in vitro，was subcutaneously transplanted into the nude mice one week after the surgery，in the irradiated group the mice were exposed to 4 Gy of total body irradiation 3 h pior to injection with endometrial cells，in the non-irradiated group the mice were injected with endometrial cells in the same time.the mice weight，survival rate and tumor growth of both groups were observed，the diameters of tumors was measured and the volume of tumors was calculated. Results：The both groups have 100% tumor growth； the difference in tumor sizes is not significant（P＜0.05）. Conclusions：Total body irradiation did not affect the tumor-take rate on human endometrial carcinoma xenografts in ovariectomized nude mice, but increased the death rate of nude mices.

Key words: Endometrial neoplasms, Neoplasm transplantation, Mice, nude, Ovariectomy, Disease models