Abstract: Birth defects is the structural or functional abnormalities already existed before birth （which can be found in a lifetime years before or after birth），and its causes including genetic，environmental and both of joint action. Environmental factors have become threats to humanity even in the reproduction of the species. Nowadays，birth defects has become one of the hot topics. This review focuses on recent environmental factors on the impact of birth defects，and focus on the ultrasound and psychological factors associated with birth defects.

Key words: Congenital abnormalities, Disorders of environmental origin, Ultrasonography, Anxiety, Depression