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15 October 2012, Volume 39 Issue 5
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To Be a Good Hysteroscopist XIA En-lan 2012, 39 (5):  409-412.  Abstract ( 1574 )   PDF (267KB) ( 5050 )   Hysteroscopy is one of the contemporary mainstream technology of minimally invasive surgery. It has been become gold standard diagnosis method and new surgical treatment model of gynecological diseases. It is no repair chance for hysteroscopic uterine renaturation surgery. Hysteroscopic air embolism complication can cause sudden death. In order to avoid adverse events，hysteroscopist not only must go through professional training， familiar with ultrasonic intervention， distension and irrigation of uterus， anesthesia monitoring， video effect， equipment and instrument performance and operating requirements， but also master laparoscopic technology. Hysteroscopist has to pay attention and carry out preoperative pretreatment of hysteroscopic surgery， to alert and prevent serious complications of hysteroscopic surgery. Through training and exercise， doctors can be a good hysteroscopist. Related Articles | Metrics

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Laparoscopy in Diagnosis of Pelvic Neoplasm LA Duan-duan;WANG Yue-ping;WU Bu-chu;LONG Wen-qing 2012, 39 (5):  413-415.  Abstract ( 1480 )   PDF (259KB) ( 5072 )   Pelvic neoplasms are common disease in clinical practice but difficult in diagnosis. Laparoscopy therapy with early consultant of clinical manifestation，ultrasound and serum tumor marker results is the most efficient treatment in pelvic neoplasms. Related Articles | Metrics

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The Clinical Decision Making of Laparoscopy for Uterine Leiomyoma LI Bin;QIU Jun-jun;HUA Ke-qin 2012, 39 (5):  416-420.  Abstract ( 1523 )   PDF (293KB) ( 5072 )   Uterine leiomyomata are the commonest neoplasms of the female reproductive system in the procreative age. In these cases operation is still a treatment of choice. Hysteroscopic，abdominal and laparoscopic myomectomy，abdominal，vaginal，and laparoscopic hysterectomy，radio frequency ablation，uterine artery embolization and focused ultrasound are now available. To date，with the advancement of surgical skills and laparoscopic instruments，clinical application of laparoscopy for uterine leiomyoma is increasingly widespread. Despite the fact that laparoscopy has proven its advantages of less trauma and ache as well as shorter hospital stay and recovery period，etc.，this technique remains controversial concerning the operative indication and procedures as well as intraoperative and postoperative complications，etc. Therefore，extensive investigation on laparoscopy for uterine leiomyoma is paramountly required. This study addresses the important aspects of the indications，contraindications，surgical procedures and complications for laparoscopic myomectomy and the operative indication and procedures for total laparoscopic hysterectomy in order to assess the clinical decision making of laparoscopy for uterine leiomyoma. Related Articles | Metrics

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A Discussion and Review of Laparoscopic Hysterectomy HUI Ning;GAO Yuan 2012, 39 (5):  421-425.  Abstract ( 1525 )   PDF (279KB) ( 5074 )   In the era of minimally invasive surgery，laparoscopic surgery has been proven to be a viable alternative under the same operation indications. Although the laparoscopic technology started rather late in China，it develops very quickly. The contraindication of laparoscopy becomes decreasing along with the developing of new techniques and apparatus. With the advanced development of laparoscopic techniques，laparoscopic gynaecological surgery provides a new way for minimally invasive surgery. It is effective，reliable，and valuable in clinical application and has such merits as minimal invasion，rapid recovery and extensive application. Laparoscopic hysterectomy has the characteristics of minimally invasive surgery. The advantages include less trauma，smaller abdominal incision and faster recovery. However，limitations and complications of this methods should not be overlooked，so the selection of the ideal pattern for certain patient is important. This article seeks to illustrate laparoscopic hysterectomy and analyzes the existing problems compared to other ways of hysterectomy，thus providing reliable theoretical basis and a new view for clinical management. Related Articles | Metrics

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Treatment Strategy of Endometriosis with Infertility MAO Yun-dong 2012, 39 (5):  426-432.  Abstract ( 1406 )   PDF (495KB) ( 4994 )   Hormonal treatment does not improve the fecundity of infertile women with endometriosis. In stage Ⅰ/Ⅱ endometriosis，laparoscopic ablation of endometrial implants has been associated with a significant improvement in live birth rates. While in women with stage Ⅲ-Ⅳ endometriosis conservative surgical treatment with laparoscopy and possible laparotomy plus GnRH agonist may increase fertility，but there is some objection. There is no evidence that the outcome is affected by the method of ablation，either electrosurgery or laser delivery systems in laparoscopy. Patients with endometriosis-associated infertility undergoing assisted reproduction respond with significantly decreased 37% pregnancy rate comparing that of women with tubal factor infertility for IVF. Prolonged use of GnRH agonist before IVF-ET in patients with endometriosis resulted in significantly higher ongoing pregnancy and implantation rates than standard controlled ovarian hyperstimulation regimens. There are some evidence supporting the idea that surgery may negatively affect ovarian reserve and other investigator consider that negatively affect will decrease to minimal by practices accumulating and protecting ovarian tissue. Patients in stage Ⅰ-Ⅱ endometriosis with infertility should be expect to nature fecundity months after laparoscopy，and who in stage Ⅲ-Ⅳ will be suggested to get assisted reproduction. There are heated argument in laparoscopy before IVF-ET/ICSI. When recurrent of endometriosis are present，more than one time IVF after GnRH agonist treatment of severe month have better pregnancy rates than laparoscopy again. Treatment with a GnRH agonist for 3-6 months before IVF in women with endometriosis increases the rate of clinical pregnancy as negative effect of fertility in many mechanisms by endometriosis. There are some introduction in Endometriosis Fertility Index（EFI），some guideline and committee opinion from European Society of Human Reproductive and Embryology（ESHRE），American Society of Reproductive Medicine （ASRM） and Chinese Medicine Association. The treatment strategy in endometriosis and infertility of author′s ART center is introduction. Related Articles | Metrics

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Gynecologists Humanistic Accomplishment and Feelings LING Bin 2012, 39 (5):  433-435.  Abstract ( 1844 )   PDF (304KB) ( 4922 )   The perfect combination of medical science and humanistic spirit is the top state of clinical medicine development. Humanistic medicine is the essence of medical education. Love is the soul of the physician. A good doctor should be reflected rigorous scientific spirit and brilliant human civilization. The healers should be proficient in medicine， familiar with philosophy，feeling of Buddhism，and has a good literary and artistic accomplishment. The responsibility of doctor is care of the patients. Excellent gynecologists should have wisdom of careful clinical thinking，minimally invasive concept and clinical skills，and be good at communication，magnanimous bosom， respecting teachers. Related Articles | Metrics

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Focus on Laparoscopy in Gynecology LENG Jin-hua;SHI Jing-hua 2012, 39 (5):  436-439.  Abstract ( 1464 )   PDF (282KB) ( 5170 )   During the last three decades，laparoscopic surgery has been widely accepted in gynecologic diseases with advantages including better vision，smaller incision，faster recovery，a shorter hospital stay，milder adhesion and lower perioperative complications. The role of laparoscopy has been expanded from congenital anomalies，myoma，ovarian cyst to deep infiltrating endometriosis，pelvic floor dysfunction，and even gynecological cancer. Recent technical advances in endoscopic instrumentation and computer-controlled system have made modern-day laparoscopy manifold （i.e. robotic laparoscopic surgery，single-port laparoscopy and natural orifice transluminal endoscopic surgery）. Several arguments on new gynecologic applications and those advanced techniques have been published recently. Gynecology doctors and technicians together make efforts on the development of laparoscopic sugery. Related Articles | Metrics

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The Prevention and Treatment of Hysteroscopic Complications CHEN Qing;ZHANG Wei-wei;LIU Chang-hao;GUAN Mei-mei 2012, 39 (5):  440-443.  Abstract ( 1630 )   PDF (262KB) ( 4998 )   Because of the security and minimal invasive，hysteroscopy has become a well-established modality to diagnose and treat the gynecological diseases. However，there are still complications connected to hysteroscopy such as uterine perforation，TURP syndrome，hemorrhage，infection and so on. Some of them is sever and fatal. Therefore，the recognition of complications and prompt intervention will prevent adverse sequelae as well as minimizing undesirable outcomes. Related Articles | Metrics

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Investigation of Nerve-Sparing Surgery for Deeply Infiltrated Endometriosis ZHANG Xin-mei 2012, 39 (5):  444-445.  Abstract ( 1454 )   PDF (173KB) ( 4950 )   In recent years，radical resection of deeply infiltrating endometriosis （DIE） has almost been reached a consensus. However，the attention to the bladder，rectum，and sexual dysfunction after surgery has rarely paid. Recent studies have shown that the pelvic autonomic nerve-sparing DIE radical surgery may avoid the bladder，rectum，and sexual dysfunction after operation. Here，we investigated the feasibility of the pelvic autonomic nerve-sparing DIE radical surgery，and the modes of operations. Related Articles | Metrics

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Application Advances of Laparoscope in Gynecologic Oncology CHEN Gong-li;LIANG Zhi-qing 2012, 39 (5):  446-451.  Abstract ( 1562 )   PDF (386KB) ( 4970 )   In the past 20 years，diagnosis and treatment of gynecological malignancies has made significant progress. Especially in recent years，with the new development of equipment which laparoscopic surgery pioneers expect，performing laparoscopic surgery in gynecologic oncology has become feasible. The laparoscopic application in the diagnosis and treatment of gynecologic malignancies has multiple benefits，including image magnification，metastatic or recurrent lesions can be found easily，at challenging areas，such as the anatomy of para-vescal space and perirectal fascia space can be clearly display. Pneumoperitoneum pressure can reduce the small blood vessels bleeding，thus reducing the length of hospital stay and recovery faster. Earlier postoperative chemotherapy or radiotherapy，can greatly reduce radiation-induced intestinal complications. Related Articles | Metrics

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The History，Situation and Future of Hysteroscopic Endometrial Ablation WANG Ming;FENG Li-min 2012, 39 (5):  452-459.  Abstract ( 2110 )   PDF (1175KB) ( 5353 )   Abnormal uterine bleeding（AUB） is a femal common disease. Endometrial ablation（EA） is one of the treatments of AUB. EA could destroy the endometrium and the superficial layer of myometrium by physical or chemical methods. When the endometrium destroyed，it will lose the potential to regenerate，then the menstruation quantity become little，even amenorrhoea and excessive uterine bleeding is avoided. Up to now，there are two generations of EA. Each generation various ways destroy the endometrium to treat menorrhagia. Though endometrial ablation is more and more safe and effective，but it still has many deficiencies，such as postoperative bleeding，infection，even pregnancy. Also，menstrual related abdominal pain，such as hematometra，post-ablation-tubal sterilization syndrome（PATSS） and still exists the risk of endometrial malignant disease. There are EA related problems need further research and the summary of evidence-based medicine. Related Articles | Metrics

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The Role of Hysteroscopy in the Evaluation of Infertility Women CHEN Zheng-yun;LIN Jun 2012, 39 (5):  460-462.  Abstract ( 2231 )   PDF (214KB) ( 6410 )   Congenital anomalies and acquired diseases of the uterus cavity may interfere with normal implantation and placentation that may lead to infertility and pregnancy loss. Hysteroscopy is considered the“gold standard” investigation for assessment of the uterine cavity，with the ability to treat uterine pathology in infertile patients. It also improves pregnancy outcome singnificantly. Hysteroscopy was even regarded as one of assisted reproduction technique by some authors. But the value of hysteroscopy as a routine approach in the management of infertile women is a matter of debate. Hysteroscopic tubal cannulation should be considered as a treatment option for women with proximal tubal obstruction because the treatment improves the chance of pregnancy. ART combineded with hysteroscopy requires further investigation. With the advantage of direct visualization，amplification，“see and treat”，and minimal invasion，hysteroscopy plays an more important role in infertility. Related Articles | Metrics

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Expanding Applications of Hysteroscopy in Diagnosis and Treatment of Endometrial Diseases GUO Qi-sang;SUI Long 2012, 39 (5):  463-467.  Abstract ( 1792 )   PDF (266KB) ( 5185 )   In recent years， many exciting innovations have been developed for either diagnostic or operative hysteroscopy，thus expanding application of hysteroscopy in the diagnosis and treatment of endometrial diseases.This paper introduces a new diagnostic endoscopic technique for endometrial diseases-narrow-banding imaging hysteroscopy. It also discusses the therapeutical application of hysteroscopy on endometrial diseases，including the conservative treantment of endometrial cancer and atypical endometrial hyperplasia， and hysteroscopic treatment of infertility resulting from intrauterine adhesions. Finally， related evidence-based issues were discussed about the dissemination of endometrial carcinoma into the peritoneal cavity. Related Articles | Metrics

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Clinical Evaluation for Hysteroscopy Combined with Laparoscopy BI Fang-fang;WANG Dan-dan;YANG Qing 2012, 39 (5):  468-470.  Abstract ( 1613 )   PDF (251KB) ( 5036 )   In recent years，along with the development of endoscopy technology，hysteroscopy combined with laparoscopy has been palying an important role in diagnosis and treatment of various gynecological diseases，with the advantages of fast，accuracy，mini-wound and so on. This paper summarizes the application of hysteroscopy combined with laparoscopy in various diseases，and evaluates its advantages and disadvantages，in order to give certain instruction to the clinical work. Related Articles | Metrics

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Staging and Classification of Endometriosis：Current Systems and the Novel YAO Classification ZHANG Huan-xiao;YAO Shu-zhong 2012, 39 (5):  471-475.  Abstract ( 1792 )   PDF (554KB) ( 5113 )   Endometriosis is a kind of common gynecologic disease，which is benign but intricate. The revised American Fertility Society（rAFS） classification system has historically beenthe only classification system and the most widely used staging system. Recently，the ENZIAN classification system，developed as an adjunct to the rAFS to describe deeply infiltrating endometriosis（DIE） and the involvement of other organs has been introduced. More recently， the Endometriosis Fertility Index （EFI） that has been validated to predict non-IVF pregnancy rates in infertility patients following surgical diagnosis and treatment of endometriosis was published. YAO Classification is a novel system that based on laparoscopic exploration and pathology. YAO Classification is better at standardizingdescription，documentation，and analysis of endometriosis，especially DIE. Related Articles | Metrics

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Clinical Study of Hysteroscopic Bipolar Plasma Electrode System Endometrial Resection XIA Ting-ting;XIANG Mei;SONG Zhen-xia;WANG Li-feng;XU Wei 2012, 39 (5):  476-478.  Abstract ( 1593 )   PDF (252KB) ( 4996 )   Objective：To investigate the effect and the safety of bipolar electrode system during endometrial resection treatment. Methods：A total of 50 patients including dysfunctional uterine bleeding and endometrial polyps were randomly divided into two groups，one including 30 cases treated with monopolar resectoscopic surgery and the other 20 cases treated with bipolar resectoscopic surgery，all of them carries on the contrast analysis. Results：The experimental group in operation time，amount of bleeding during the operation，the volume of uterine distention medium and absorption volume，were lower than the control group, difference between the two groups is statistically significant（P＜0.05），the experimental group without the occurrence of uterine perforation，air embolism，transurethral resection of prostate syndrome（TURPS），and can maintain the balance of blood electrolyte；the number of days of vaginal bleeding or discharge liquid of experimental group is less than the control group（t=4.254，P＜0.001）；the treatment effect of the two groups had no significant difference（χ2=0.591，P=0.807）. Conclusions：The bipolar electrode system during endometrial resection is fast，safe，effective，and is worthy of further promotion. Related Articles | Metrics

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Study on Hysteroscopy-assisted Diagnosis and Treatment of Oblique Vaginal Septum Syndrome WANG Li-feng;XIANG Mei;XIA Ting-ting;XU We 2012, 39 (5):  479-482.  Abstract ( 1417 )   PDF (361KB) ( 4960 )   Objective：To study the clinicle value of hysteroscopy in diagnosis and treatment of oblique vaginal septum syndrome. Methods：13 patients（7 cases of typeⅠ，1 cases with congenital urethrovaginal fistula，6 cases of type Ⅲ，Ⅱ） with oblique vaginal septum syndrome（OVSS） are enrolled from 2003 January to 2011 December. A systematic retrospective analysis，age 11-20 years old，average age is 13.6±2.8 years old，with abdominal pain after menarche，periodic abdominal pain or a pelvic mass was detected on admission，preoperative hysteroscopy combined with ultrasonography can make clear the clinical diagnosis. Hysteroscopy can find total reproductive development，guide and locate the septum position. Incision and resection of oblique vaginal septum，removal of vaginal or intrauterine hematocele or empyema. Results：Postoperative dysmenorrhea symptom disappeared，the volume no change，no vaginal or abdominal mass happened again. Conclusions：In diagnosis of oblique vaginal septum, hysteroscopy is an important means， combined with ultrasound examination to clearly understand reproductive development and localize of oblique vaginal septum position，guide operation resection or clear cut parts. By hysteroscopy and ultrasonography can make oblique vaginal septum operation more accurate，safe，fast，and direct. Related Articles | Metrics

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Research Progress on Environment Factors Leading to Birth Defects CAI Jing;YANG Jing 2012, 39 (5):  483-486.  Abstract ( 1368 )   PDF (280KB) ( 5076 )   Birth defects is the structural or functional abnormalities already existed before birth （which can be found in a lifetime years before or after birth），and its causes including genetic，environmental and both of joint action. Environmental factors have become threats to humanity even in the reproduction of the species. Nowadays，birth defects has become one of the hot topics. This review focuses on recent environmental factors on the impact of birth defects，and focus on the ultrasound and psychological factors associated with birth defects. Related Articles | Metrics

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The Research Status and Significance of Female Pelvic Arterial System ZHU Jiang-hong;XU Yu-jing;LIU Ping;CHEN Chun-lin 2012, 39 (5):  487-490.  Abstract ( 1604 )   PDF (237KB) ( 4966 )   Female pelvic arterial system is a huge and complex arterial system and the development of its research methods could be largely divided into two phases，autopsy and in vivo research. Due to the numbered corpses，it is almost impossible to promote a large scale study based on the data collected from corpses. For in vivo research，at present，magnetic resonance angiography and computed tomography angiography could offer a far more clear view of female pelvic artery than X-ray and ultrasound，which earn them a substantial popularity in this field of study. And the roles of X-ray and ultrasound have been gradually replaced by magnetic resonance angiography and computed tomography angiography. In recent years，the three-dimensional reconstruction technique is developing rapidly and has been considered as the most competitive method to research pelvic artery system owing to the in vivo individualized images. There exist ethnic differences and individual variation in female pelvic arterial system. Besides the developmental changes of female pelvic artery should not be ignored. Therefore，it is of great significance to investigate the female pelvic artery system，for the knowledge of it is helpful to diagnose pelvic diseases and guide pelvic surgery and uterine artery embolization. Related Articles | Metrics

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Progress on Endometrial Receptivity of the Polycystic Ovary Syndrome YE Cai-yun;YANG Xue-feng 2012, 39 (5):  491-494.  Abstract ( 1509 )   PDF (252KB) ( 4933 )   The polycystic ovary syndrome（PCOS） is one of the most common endocrinopathy of reproductive-aged women in Gynecology. There is increasing evidence showing that the disorder of endometrial development and the decrease of endometrial receptivity to blastocyst implantation may be one of causes contributing to the poor abilities of reproduction and the unsatisfied outcomes of pregnancy in PCOS patients. Aberrant expression of some molecules and genes in endometrium may contribute to diminished endometrial receptivity. The article reviewed the latest progress in the well-known characteristic markers of endometrial receptivity at present，such as，the steroid hormones of ovary and their receptors，cell adhesion molecules，matrix metalloproteinase，Leukemia inhibitory factor and so on. Related Articles | Metrics

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Recent Progress in the Pathogenesis of Type A Insulin Resistance Syndrome WANG Guan-yi;XU Lan 2012, 39 (5):  495-498.  Abstract ( 2552 )   PDF (234KB) ( 4925 )   As a rare type of autosomal recessive inheritanced insulin resistance syndrome，type A insulin resistance syndrome（TAIRS） is caused by mutations in the insulin receptor gene which induces insulin dysfunction and a series of physiological and pathological abnormalities due to defective binding of insulin to its receptors. Rarely diagnosed clinically，TAIRS is mainly characterized by severe insulin resistance，hyperinsulinemia，hyperandrogenism，and acanthosis nigricans. At present there is no explicit TAIRS diagnosis standard，and the diagnosis is mainly based on the clinical symptoms and insulin receptor gene screening. There is no radical treatment means. We just improve insulin resistance and alleviate the symptoms. Related Articles | Metrics

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Steroidogenic Factor 1：Its Role in the Pathogenesis of Endometriosis FU Guo-fang;ZHANG Xin-mei 2012, 39 (5):  499-502.  Abstract ( 1281 )   PDF (234KB) ( 4936 )   Endometriosis is an estrogen-dependent disease. Local estrogen biosynthesis is a major factor in the pathogenesis of endometriosis. Aromatase is a key enzyme during the process of estrogen biosynthesis. Recent studies have demonstrated that aromatase both in eutopic and ectopic endometrium of patients with endometriosis expressed highly，but didn′t express in the normal endometrium，and there were several successful treatment cases of endometriosis with aromatase inhibitors. However，recent studies have found that steroidogenic factor 1（SF-1） didn′t express in normal endometrial stromal cells，but highly expressed in ectopic stromal cells. SF-1 plays an important role in the synthesis of aromatase. The level of SF-1 directly affected the expression of aromatase，while the abnormal expression of SF-1 mainly due to the hypermethylation of SF-1 gene promoter region. In this paper，we make a review about the role of SF-1 playing in the pathogenesis of endometriosis. Related Articles | Metrics

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Relationship Between Endometriotic Pain and Antagonist of Bradykinin B1 Receptor ZHANG Hai-yan;ZHU Zhi-ling 2012, 39 (5):  503-506.  Abstract ( 1471 )   PDF (282KB) ( 4977 )   Endometriosis is defined as ectopic endometrium locates outside the cavity of uterus，with pain as the most distinguish clinical manisfestation. So far，the pathogenesis of the pain in endometriosis is unclear yet. Bradykinin is the strongest algogen，and bradykinin B1 receptor is considered as one of the main factors that maintain inflammation and pain. Previous studies have revealed that bradykinin B1 receptor antagonist could effectively be used in treating inflammation and pain. Recent research progress on endometriotic pain and bradykinin B1 receptor antagonist has been reviewed in this article. Related Articles | Metrics

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Progress of Laparoscopic Surgery for Deep Infiltrating Endometriosis CHE Xuan;ZHANG Xin-mei 2012, 39 (5):  507-509.  Abstract ( 1598 )   PDF (446KB) ( 5294 )   Surgical treatment is a main option for deep infiltrating endometriosis （DIE）. Laparoscopic complete excision of endometriosis is a priority option due to a high rate of pain relief and a low rate of recurrence. However，the radical surgery of DIE leading to the dysfunction of the bladder and rectum is worthy of increasing attention. Recently，laparoscopic nerve-sparing complete excision of endometriosis is considered to reduce or avoid the dysfunction of bladder，rectum and sexuality . This article reviews the recent research progress of laparoscopic nerve-sparing complete excision of DIE. Related Articles | Metrics

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Update of Current Evidence-based Literatures on Sentinel Lymph Node Evaluation in Gynecologic Malignancies MA Xiao-jing;MENG Xiang-ju 2012, 39 (5):  510-513.  Abstract ( 1507 )   PDF (196KB) ( 5019 )   Sentinel lymph node（SLN） dissection has been shown to be important for staging of malignant tumor and safe for selection of alternative surgical approachs. SLN has also been shown to be associated with decreased short-term and long-term morbidity when compared with complete lymph node dissection. There has been increasing interest in the usage of SLN technology in gynecologic cancers. This review assesses the current evidence-based literature for the usage of SLN dissection in gynecologic malignancies. Related Articles | Metrics

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Application of Gonadotrophin-Releasing Hormone Analogs in Malignant Gynecological Neoplasms LIU Shi-ping;YANG Jia-xin 2012, 39 (5):  514-517.  Abstract ( 1540 )   PDF (290KB) ( 4967 )   According to its mechanisms of action，gonadotrophin-releasing hormone analogs　（GnRH-A）　are divided into two categories：agonist and antagonist． It has been demonstrated that 80% of ovarian and endometrial cancers express GnRH and its receptors． The anti-cancer role of GnRH-A is played either by suppressing the hypothalamic-pituitary axis or through its autocrine and paracrine systems． GnRH-A had been used in the treatment of advanced or recurrent endometrial and ovarian cancers，but the effect is no better than other second-line drugs．These days，the application of GnRH-A in the preservation of fertility and ovarian function has become increasingly popular． Besides，the use of GnRH-A in molecular targeted therapy is also promising. Related Articles | Metrics

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Analysis of Gene Expression Profile in HeLa Cells Upregulated Expression of MicroRNA-205 by cDNA Microarray WEI Li-ya;YAO Ting-ting;CHEN Qing-yu;SHEN Qing-li;LIN Zhong-qiu 2012, 39 (5):  518-520.  Abstract ( 1519 )   PDF (280KB) ( 4945 )   Objective：To identify a set of genes related to upregulated expression of miR-205 in HeLa cells and to investigate their function，and to discuss the pathogenesis of cervical cancer. Methods：The HeLa cells upregulated expression of miR-205 and normal HeLa cells were analyzed with 23 232 human genes of cDNA microarrays. Results：A total of 172 differential genes expressed in the HeLa cells upregulated expression of miR-205 were screened out，of which，34 were up regulated and 138 were down regulated. Conclusions：The cDNA microarray is a powerful method to identify the gene expression profile. Cervical cancer induced by upregulated expression of miR-205 is a result of coeffecting by polygene and multiple factors. Related Articles | Metrics

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Current Situation and Thinking of Abdominal Wall Incision Endometriosis After Cesarean Section in China ZHANG Hong-hui;XING Hua-ying;LIU Xu-fang;JIANG Ying-min;GE Zhi-juan;ZOU He-mei;FEI Cui-qin 2012, 39 (5):  521-524.  Abstract ( 1590 )   PDF (299KB) ( 5143 )   Objective：To investigate Chinese current situation of secondary abdominal wall endometriosis after cesarean section incision . Methods：In “China know nets（CNKI）” the home page，especially into the theme retrieval，input “method” and including “endometriosis”，select “accurate”，and click “retrieval literature”，ideally suited to learn about “after cesarean section abdominal incision endometriosis” articles，click “the author unit” of the province/municipality and “published time” in the annual statistical analysis. Results：① in CNKI，“after cesarean section abdominal incision endometriosis” literature is a total of 427 article，total 5 169 patients，“the author unit” of the province/involved were 29，85.29%（29/34） municipality were involved. The top five provinces is Jiangsu，Zhejiang，Henan，Shandong and Sichuan provinces，the last five is mingier，Fujian，Jiangxi，Gansu and Qinghai provinces. ② in CNKI，about “after cesarean section abdominal incision endometriosis” aspects of the article，first published in 1984，there were 70 articles in earlier 20 years，accounted for 16.39%. After 2004，the incidence has increased year by year，then reached to 18.03% in 2010. Conclusions：①After cesarean section abdominal incision endometriosis， the pathogenic factors support endometrial “planting theory”. ②The abdominal incisions endometriosis after cesarean section displays obviously regional characteristic，probably closely related with its “model” section. ③The cesarean section postoperative abdominal incision endometriosis increases year by year. ④The improvement of “cesarean section postoperative abdominal incision endometriosis”awareness，strict control of cesarean section indications，control the rate of cesarean section，enhance the quality of operation，reduce abdominal incision endometriosis key initiatives，perhaps also key to reduce or eliminate the medical disputes in the future. Related Articles | Metrics

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Investigation on the Nutrition Knowledge，Attitude，and Practice of Pregnant Women in Zhengzhou WANG Hui-jun;WANG Jian-she;WANG Hui-ling;SUN Su-xia 2012, 39 (5):  525-527.  Abstract ( 1573 )   PDF (229KB) ( 4877 )   Objective：To investigate and analyze the nutrition knowledge，attitude and practice among pregnant women，for scientific evidence of better grasp of nutrition knowledge and more targered nutrition guide. Methods：392 pregnant women in Yellow River Central Hospital were selected randomly to investigate their nutrition knowledge，attitude，practice （KAP） by a self-designed questionnaire. Data were inputed using Epidata 3.1. Statistical analyses were performed using SPSS 13.0. Results：Most pregnant women lacked a overall understanding of nutritional knowledge and practice，however，they held a positive attitude towards nutrition. They hoped to obtain more professional knowledge from medical staff. Conclusions：Doctors and nurses should improve the nutritional level of knowledge，strengthen health care for pregnant women，and to improve pregnant women nutrition knowledge and attitudes and to change its unhealthy eating behaviors，and improve mother and children′s health. Related Articles | Metrics

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Clinical Value and Ultrasound Screening of Fetal Single Umbilical Artery WU Jing;HUANG Jian;WU Zhong-yu 2012, 39 (5):  528-529.  Abstract ( 1575 )   PDF (7389KB) ( 5052 )   Objective：To evaluate the clinical role and the ultrasonographic features in prenatal diagnosis of single umbilical artery（SUA） in Tianjin. Methods：To review 40 fetuses with SUA found in our hospital from December 2007 to July 2009 in Tianjin. Their clinical manifestation and pregnancy outcome were followed up. Results：In 40 cases，only single umbilical artery could be detected by ultrasonography. Among them，5 cases combined with other abnormalities by ultrasonography，1 case was induced of labor because of intrauterine fetal death. In the cases going on with their pregnancy，12 cases had disorders during the pregnancy course or the labor，7 cases were found to be combined with other abnormalities. Conclusions：Ultrasound-Doppler can diagnose the SUA correctly. When we find a fetus with SUA，we should analyze it from different aspect to except other organic malformations. To the cases going on with their pregnancy，we must pay more attention to the fetuses growth and delivery. Related Articles | Metrics

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Clinical Analysis of Diagnosis and Treatment for 66 Cases of Acute Appendicitis During Pregnancy SU Nai-wei;LI Xin-ning;SHI Qun-feng 2012, 39 (5):  530-532.  Abstract ( 1604 )   PDF (211KB) ( 5004 )   Objective：To explore diagnosis and treatment of acute appendicitis during pregnancy. Methods：retrospective analysis of the clinical data of 66 cases of acute appendicitis during pregnancy，29 patients didn't agree with surgery，so received conservative treatment，and 12 cases of uncontrolled infection，change to surgical treatment，37 cases were admitted to the hospital emergency surgical treatment. Results：66 patients discharge smoothly；eight patients after discharge required abortion in obstetrics and gynecology；2 patients had the abortion，one patient was premature birth at 10 days after surgery；no serious complications such as fetal distress，stillbirth and pregnant women death. Conclusions：Important means for the safety of maternal and infant is that timely diagnosis and surgical treatment of acute appendicitis during pregnancy. If symptoms of light infection，unapparent local peritonitis，and patients don't agree with surgery，we first do conservative treatment，and closely observe. If the treatment effect is not obvious，we then immediately surgery. Related Articles | Metrics

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Experimental Study of Mefordcare Phytic Acid Ketone Effect on HeLa Cells Using MTT Assay WU Zhi-dan;YANG Zhi-mou;YUE Tian-fu 2012, 39 (5):  533-534.  Abstract ( 1971 )   PDF (7419KB) ( 5144 )   Objective：To study the ability of the No.1 and No.2 of type Ⅱ of Mefordcare Phytic Acid Ketone on inhibiting the proliferation of HeLa cells which were cultivated in vitro，and provide the evidence for futher experiment. Methods：The HeLa cells which were cultivated in vitro was treated by eight different concentrations for 24，48 and 72h，MTT assay was employed to examine the growth suppression of HeLa cells. Results：Contrast with the control group，the apoptosis of the cells treated with these two numbers of the drug was increased and the growth rate was decreased. And the inhibition of HeLa cells in partly is in a concentration-dependent and time-dependent manner. Conclusions：The No.1 and No.2 of type Ⅱ of Mefordcare Phytic Acid Ketone could significantly inhibit the proliferation of HeLa cells. Related Articles | Metrics